{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:09:14Z","timestamp":1760080154913},"reference-count":17,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,10,1]]},"abstract":"<jats:p>Three different levels of hyperchloremia were induced in healthy Friesian calves to study the effects of chloride on blood oxygen transport. By infusion, the calves received either 5 ml\/kg of 0.9% NaCl (low-level hyperchloremia; group A), 5 ml\/kg of 7.5% NaCl (moderate hyperchloremia; group B), or 7.5 ml\/kg of 7.5% NaCl (high-level hyperchloremia; group C). Blood was sampled from the jugular vein and the brachial artery. Chloride concentration, hemoglobin content, arterial and venous pH, [Formula: see text], and[Formula: see text] were determined. At each time point (0, 15, 30, 60, and 120 min), the whole blood oxygen equilibrium curve (OEC) was measured under standard conditions. In groups B and C, hyperchloremia was accompanied by a sustained rightward shift of the OEC, as indicated by the significant increase in the standard [Formula: see text] at 50% hemoglobin saturation. Infusion of hypertonic saline also induced relative acidosis. The arterial and venous OEC were calculated, with body temperature, pH, and [Formula: see text] values in arterial and venous blood taken into account. The degree of blood desaturation between the arterial and the venous compartments [O<jats:sub>2<\/jats:sub>exchange fraction (OEF%)] and the amount of oxygen released at tissue level by 100 ml of bovine blood (OEF vol%) were calculated from the arterial and venous OEC combined with the [Formula: see text] and hemoglobin concentration. The chloride-induced rightward shift of the OEC was reinforced by the relative acidosis, but the altered[Formula: see text] values combined with the lower hemoglobin concentration explained the absence of any significant difference in OEF (% and vol%). We conclude that infusion of hypertonic saline induces hyperchloremia and acidemia, which can explain the OEC rightward shift observed in arterial and peripheral venous blood.<\/jats:p>","DOI":"10.1152\/jappl.1998.85.4.1267","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:40:13Z","timestamp":1513975213000},"page":"1267-1272","source":"Crossref","is-referenced-by-count":16,"title":["Effects of hyperchloremia on blood oxygen binding in healthy calves"],"prefix":"10.1152","volume":"85","author":[{"given":"C.","family":"Cambier","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Li\u00e8ge, B-4000 Li\u00e8ge; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Detry","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pneumology, Cliniques Universitaires Saint-Luc, Catholic University of Louvain, B-1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Beerens","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Li\u00e8ge, B-4000 Li\u00e8ge; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Florquin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Li\u00e8ge, B-4000 Li\u00e8ge; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ansay","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Li\u00e8ge, B-4000 Li\u00e8ge; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Frans","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pneumology, Cliniques Universitaires Saint-Luc, Catholic University of Louvain, B-1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Clerbaux","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pneumology, Cliniques Universitaires Saint-Luc, Catholic University of Louvain, B-1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gustin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Li\u00e8ge, B-4000 Li\u00e8ge; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.1395"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005804102715"},{"key":"B3","first-page":"1","volume":"30","author":"Clerbaux T.","year":"1973","journal-title":"Med. 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