{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:36:38Z","timestamp":1791398198512,"version":"4.3.3"},"reference-count":34,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,10,1]]},"abstract":"<jats:p>\n                    The purpose of the present study was to determine the effect on breathing in the awake state of carotid body denervation (CBD) over 1\u20132 wk after denervation. Studies were completed on adult goats repeatedly before and 1) for 15 days after bilateral CBD ( n = 8), 2) for 7 days after unilateral CBD ( n = 5), and 3) for 15 days after sham CBD ( n = 3). Absence of ventilatory stimulation when NaCN was injected directly into a common carotid artery confirmed CBD. There was a significant ( P &lt; 0.01) hypoventilation during the breathing of room air after unilateral and bilateral CBD. The maximum [Formula: see text] increase (8 Torr for unilateral and 11 Torr for bilateral) occurred \u223c4 days after CBD. This maximum was transient because by 7 (unilateral) to 15 (bilateral) days after CBD, [Formula: see text]was only 3\u20134 Torr above control. CO\n                    <jats:sub>2<\/jats:sub>\n                    sensitivity was attenuated from control by 60% on day 4 after bilateral CBD and by 35% on day 4after unilateral CBD. This attenuation was transient, because CO\n                    <jats:sub>2<\/jats:sub>\n                    sensitivity returned to control temporally similar to the return of[Formula: see text] during the breathing of room air. During mild and moderate treadmill exercise 1\u20138 days after bilateral CBD, [Formula: see text] was unchanged from its elevated level at rest, but, 10\u201315 days after CBD,[Formula: see text] decreased slightly from rest during exercise. These data indicate that 1) carotid afferents are an important determinant of rest and exercise breathing and ventilatory CO\n                    <jats:sub>2<\/jats:sub>\n                    sensitivity, and 2) apparent plasticity within the ventilatory control system eventually provides compensation for chronic loss of these afferents.\n                  <\/jats:p>","DOI":"10.1152\/jappl.1998.85.4.1299","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T15:40:13Z","timestamp":1513957213000},"page":"1299-1306","source":"Crossref","is-referenced-by-count":76,"title":["Important role of carotid afferents  in control of breathing"],"prefix":"10.1152","volume":"85","author":[{"given":"L. 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