{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:36:51Z","timestamp":1773419811820,"version":"3.50.1"},"reference-count":36,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:p>It is hypothesized that carotid body chemosensory activity is coupled to neurosecretion. The purpose of this study was to examine whether there was a correspondence between carotid body tissue dopamine (DA) levels and neuronal discharge (ND) measured from the carotid sinus nerve of perfused cat carotid bodies and to characterize interaction between CO<jats:sub>2<\/jats:sub>and O<jats:sub>2<\/jats:sub>in these responses. ND and tissue DA were measured after changing from normoxic, normocapnic control bicarbonate buffer ([Formula: see text]&gt;120 Torr, [Formula: see text] 25\u201330 Torr, pH \u223c 7.4) to normoxic hypercapnia ([Formula: see text] 55\u201357 Torr, pH 7.1\u20137.2) or to hypoxic solutions ([Formula: see text] 30\u201335 Torr) with normocapnia ([Formula: see text] 25\u201330 Torr, pH \u223c 7.4) or hypocapnia ([Formula: see text]10\u201315 Torr, pH 7.6\u20137.8). Similar temporal changes for ND and tissue DA were found for all of the stimuli, although there was a much different proportional relationship for normoxic hypercapnia. Both ND and DA increased above baseline values during flow interruption and normocapnic hypoxia, and both decreased below baseline values during hypoxic hypocapnia. In contrast, normoxic hypercapnia caused an initial increase in ND, from a baseline of 175 \u00b1 12 (SE) to a peak of 593 \u00b1 20 impulses\/s within 4.6 \u00b1 0.9 s, followed by adaptation, whereas ND declined to 423 \u00b1 20 impulses\/s after 1 min. Tissue DA initially increased from a baseline of 17.9 \u00b1 1.2 \u03bcM to a peak of 23.2 \u00b1 1.2 \u03bcM within 3.0 \u00b1 0.7 s, then declined to 2.6 \u00b1 1.0 \u03bcM. The substantial decrease in tissue DA during normoxic hypercapnia was not consistent with the parallel changes in DA with ND that were observed for hypoxic stimuli.<\/jats:p>","DOI":"10.1152\/jappl.1998.85.5.1719","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:33:15Z","timestamp":1513974795000},"page":"1719-1726","source":"Crossref","is-referenced-by-count":25,"title":["Dopamine, sensory discharge, and stimulus interaction with CO<sub>2<\/sub>and O<sub>2<\/sub>in cat carotid body"],"prefix":"10.1152","volume":"85","author":[{"given":"D. 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