{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:18:24Z","timestamp":1773757104729,"version":"3.50.1"},"reference-count":33,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:p> Upper airway compliance indicates the potential of the airway to collapse and is relevant to the pathogenesis of obstructive sleep apnea. We hypothesized that compliance would vary over the rostral-to-caudal extent of the pharyngeal airway. In a paralyzed isolated upper airway preparation in cats, we controlled static upper airway pressure during magnetic resonance imaging (MRI, 0.391-mm resolution). We measured cross-sectional area and anteroposterior and lateral dimensions from three-dimensional reconstructed MRIs in axial slices orthogonal to the airway centerline. High-retropalatal (HRP), midretropalatal (MRP), and hypopharyngeal (HYP) regions were defined. Regional compliance was significantly increased from rostral to caudal regions as follows: HRP &lt; MRP &lt; HYP ( P &lt; 0.0001), and compliance differences among regions were directly related to collapsibility. Thus our findings in the isolated upper airway of the cat support the hypothesis that regional differences in pharyngeal compliance exist and suggest that baseline regional variations in compliance and collapsibility may be an important factor in the pathogenesis and treatment of obstructive sleep apnea. <\/jats:p>","DOI":"10.1152\/jappl.1998.85.5.1884","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:33:15Z","timestamp":1513974795000},"page":"1884-1897","source":"Crossref","is-referenced-by-count":14,"title":["MRI study of regional variations of pharyngeal wall  compliance in cats"],"prefix":"10.1152","volume":"85","author":[{"given":"Michael J.","family":"Brennick","sequence":"first","affiliation":[{"name":"Center for Sleep and Respiratory Neurobiology, University of Pennsylvania Medical Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm D.","family":"Ogilvie","sequence":"additional","affiliation":[{"name":"Center for Sleep and Respiratory Neurobiology, University of Pennsylvania Medical Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan S.","family":"Margulies","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pennsylvania,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Hiller","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pennsylvania,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren B.","family":"Gefter","sequence":"additional","affiliation":[{"name":"Thoracic Imaging, Department of Radiology, Hospital of the University of Pennsylvania, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan I.","family":"Pack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"(With the Technical Assistance of Ed Jensen)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.5.2026"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(85)90102-1"},{"key":"B4","first-page":"211","volume":"132","author":"Brown I. 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