{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:54:07Z","timestamp":1773420847142,"version":"3.50.1"},"reference-count":18,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:p> During ventilatory acclimatization to hypoxia (VAH), the relationship between ventilation (V\u02d9e) and end-tidal[Formula: see text]([Formula: see text]) changes. This study was designed to determine 1) whether these changes can be seen early in VAH and 2) if these changes are present, whether the responses differ between isocapnic and poikilocapnic exposures. Ten healthy volunteers were studied by using three 8-h exposures: 1) isocapnic hypoxia (IH), end-tidal [Formula: see text]([Formula: see text]) = 55 Torr and[Formula: see text] held at the subject\u2019s normal prehypoxic value; 2) poikilocapnic hypoxia (PH),[Formula: see text] = 55 Torr; and 3) control (C), air breathing. TheV\u02d9e-[Formula: see text]relationship was determined in hyperoxia ([Formula: see text]\u2009=\u2009200 Torr) before and after the exposures. We found a significant increase in the slopes ofV\u02d9e-[Formula: see text]relationship after both hypoxic exposures compared with control (IH vs. C, P &lt; 0.01; PH vs. C, P &lt; 0.001; analysis of covariance with pairwise comparisons). This increase was not significantly different between protocols IH and PH. No significant changes in the intercept were detected. We conclude that 8 h of hypoxia, whether isocapnic or poikilocapnic, increases the sensitivity of the hyperoxic chemoreflex response to CO<jats:sub>2<\/jats:sub>. <\/jats:p>","DOI":"10.1152\/jappl.1998.85.5.1922","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:33:15Z","timestamp":1513974795000},"page":"1922-1928","source":"Crossref","is-referenced-by-count":34,"title":["Human ventilatory response to CO<sub>2<\/sub> after 8 h  of isocapnic or poikilocapnic hypoxia"],"prefix":"10.1152","volume":"85","author":[{"given":"Marzieh","family":"Fatemian","sequence":"first","affiliation":[{"name":"University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Robbins","sequence":"additional","affiliation":[{"name":"University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1957.10.1.81"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1159\/000194206"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.4.665"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1968.24.5.607"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.4.1236"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.31.4.586"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.1.58"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.3.1088"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.3.1098"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.3.1092"},{"key":"B13","first-page":"7P","volume":"394","author":"Howson M. 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