{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:54:42Z","timestamp":1715594082892},"reference-count":25,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:p>To study whether a sepsis-induced increase in des-Arg<jats:sup>9<\/jats:sup>-bradykinin (des-Arg<jats:sup>9<\/jats:sup>-BK) and bradykinin (BK) B<jats:sub>1<\/jats:sub>-receptor activity participates in the observed increase in pulmonary vascular resistance in neonatal group B streptococcal sepsis (GBS), isometric force bioassays of pulmonary artery (PA) rings were studied, after 4-h exposure to either Krebs or GBS, by using the following protocols: 1) BK dose-response curve, 2) vascular response to BK with N<jats:sup>G<\/jats:sup>-nitro-l-arginine methyl ester (l-NAME), and 3) response to des-Arg<jats:sup>9<\/jats:sup>-BK (BK metabolite and B<jats:sub>1<\/jats:sub>agonist). PA rings exposed to BK resulted in contraction in the GBS group and a decrease in resting tension in the Control group ( P = 0.034) at a concentration of 10<jats:sup>\u22125<\/jats:sup>M. GBS-treated PA rings contracted more to des-Arg<jats:sup>9<\/jats:sup>-BK than did Controls ( P &lt; 0.001). BK (10<jats:sup>\u22126<\/jats:sup>M) relaxed preconstricted PA rings incubated in GBS less than BK relaxed Controls ( P &lt; 0.001), and preincubation withl-NAME decreased relaxation in both. These results suggest that GBS decreased endothelium-dependent BK relaxation and increased contractile response to des-Arg<jats:sup>9<\/jats:sup>-BK. We speculate that this occurs secondary to upregulation of B<jats:sub>1<\/jats:sub>receptors reflected by B<jats:sub>1<\/jats:sub>-agonist-mediated PA contraction.<\/jats:p>","DOI":"10.1152\/jappl.1999.86.1.61","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T13:03:36Z","timestamp":1513947816000},"page":"61-65","source":"Crossref","is-referenced-by-count":4,"title":["Influence of group B streptococci on piglet pulmonary artery response to bradykinin"],"prefix":"10.1152","volume":"86","author":[{"given":"Richard M.","family":"Whitehurst","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33101;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Laskey","sequence":"additional","affiliation":[{"name":"The Upjohn Company, Kalamazoo, Michigan 49006;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald N.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33101;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Herbert","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of South Alabama, Mobile, Alabama 36688; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius","family":"Van Breemen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008447"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90200-1"},{"issue":"31","key":"B3","first-page":"H1474","volume":"262","author":"Cornfield D. 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