{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:38:18Z","timestamp":1790879898402,"version":"4.1.0"},"reference-count":21,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:p> When airways constrict, the surrounding parenchyma undergoes stretch and distortion. Because of the mechanical interdependence between airways and parenchyma, the material properties of the parenchyma are important factors that modulate the degree of bronchoconstriction. The purpose of this study was to investigate the effect of changes in transpulmonary pressure (Ptp) and induced constriction on parenchymal bulk ( k) and shear (\u03bc) moduli. In excised rat lungs, pressure was measured at the airway opening, and pressure-volume curves were obtained by imposing step decreases in volume with a calibrated syringe from total lung inflation. Calculation was made of k during small-volume oscillations (1 Hz). Absolute lung volume at 0 cmH<jats:sub>2<\/jats:sub>O Ptp was obtained by saline displacement. To calculate \u03bc, a lung-indentation test was performed. The lung surface was deformed with a cylindrical punch (diameter = 0.45 cm) in 0.25-mm increments, and the force required to effect this displacement was measured by a weight balance. Measurements of k and \u03bc were obtained at 4 and 10 cmH<jats:sub>2<\/jats:sub>O Ptp, and again at 4 cmH<jats:sub>2<\/jats:sub>O Ptp, after delivery of methacholine aerosol (100 mg\/ml) into the trachea. Values of k and \u03bc in rat lungs were similar to those reported in other species. In addition, k and \u03bc were dependent on Ptp. After induced constriction, k and \u03bc increased significantly. That k and \u03bc can increase after induced constriction has important implications vis a vis the factors modulating airway narrowing. <\/jats:p>","DOI":"10.1152\/jappl.1999.86.1.66","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T13:03:36Z","timestamp":1513947816000},"page":"66-70","source":"Crossref","is-referenced-by-count":22,"title":["Elastic moduli of excised constricted rat lungs"],"prefix":"10.1152","volume":"86","author":[{"given":"Francesco G.","family":"Salerno","sequence":"first","affiliation":[{"name":"Meakins-Christie Laboratories, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H2X 2P2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara S.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H2X 2P2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.1.231"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.2.616"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.6.1880"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.3.1324"},{"issue":"14","key":"B5","first-page":"L962","volume":"270","author":"Fukui M.","year":"1996","journal-title":"Am. 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