{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:03:47Z","timestamp":1791198227323,"version":"4.1.0"},"reference-count":30,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,2,1]]},"abstract":"<jats:p>Exercise, salt restriction, and\/or dehydration causes transient reductions in renal function that may be buffered by vasodilatory prostaglandins (PGs). Over-the-counter (OTC) analgesics have the potential to alter renal hemodynamics by inhibiting renal PGs. Therefore, we tested the renal effects of the maximal recommended dose of acetaminophen (Acet, 4 g\/day) and ibuprofen (Ibu, 1.2 g\/day) vs. a placebo (Pl) in humans subjected to progressive renal stresses. After baseline measurements, 12 fit young (25 \u00b1 1 yr) men and women underwent 3 days of a low (10 meq\/day)-sodium diet while taking one of the drugs or Pl (crossover design). Day 4 involved dehydration (\u22121.6% body wt) followed by 45 min of treadmill exercise (65% maximal O<jats:sub>2<\/jats:sub>uptake) in the heat (36\u00b0C). These combined stressors caused dramatic decreases in effective renal plasma flow, glomerular filtration rate (GFR), and sodium excretion. Baseline GFR (range: 118\u2013123 ml\/min) decreased to 78 \u00b1 4, 73 \u00b1 5, and 82 \u00b1 5 ml\/min postexercise in the Acet, Ibu, and Pl trials, respectively, with a significantly greater decrease in GFR in the Ibu trial ( P &lt; 0.05 vs. Pl). OTC Ibu has small but statistically significant effects on GFR during exercise in a sodium- and volume-depleted state; OTC Acet was associated with no such effects.<\/jats:p>","DOI":"10.1152\/jappl.1999.86.2.598","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T12:51:26Z","timestamp":1513947086000},"page":"598-604","source":"Crossref","is-referenced-by-count":65,"title":["Effects of acetaminophen and ibuprofen on renal function in the stressed kidney"],"prefix":"10.1152","volume":"86","author":[{"given":"W. B.","family":"Farquhar","sequence":"first","affiliation":[{"name":"Noll Physiological Research Center, Pennylvania State University, University Park, Pennsylvania 16802-6900; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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