{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:48:36Z","timestamp":1793692116464,"version":"4.5.1"},"reference-count":48,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:p>We hypothesized that progesterone-mediated ventilatory stimulation during the midluteal phase of the menstrual cycle would increase exercise minute ventilation (V\u02d9e; l\/min) at sea level (SL) and with acute altitude (AA) exposure but would only increase arterial O<jats:sub>2<\/jats:sub>saturation ([Formula: see text], %) with AA exposure. We further hypothesized that an increased exercise[Formula: see text] with AA exposure would enhance O<jats:sub>2<\/jats:sub>transport and improve both peak O<jats:sub>2<\/jats:sub>uptake (V\u02d9o<jats:sub>2 peak<\/jats:sub>; ml \u22c5 kg<jats:sup>\u22121<\/jats:sup>\u22c5 min<jats:sup>\u22121<\/jats:sup>) and submaximal exercise time to exhaustion (Exh; min) in the midluteal phase. Eight female lowlanders [33 \u00b1 3 (mean\u2009\u00b1\u2009SD) yr, 58 \u00b1 6 kg] completed aV\u02d9o<jats:sub>2 peak<\/jats:sub>and Exh test at 70% of their altitude-specificV\u02d9o<jats:sub>2 peak<\/jats:sub>at SL and with AA exposure to 4,300 m in a hypobaric chamber (446 mmHg) in their early follicular and midluteal phases. Progesterone levels increased ( P &lt; 0.05) \u223c20-fold from the early follicular to midluteal phase at SL and AA. PeakV\u02d9e (101 \u00b1 17) and submaximalV\u02d9e (55 \u00b1 9) were not affected by cycle phase or altitude. Submaximal[Formula: see text] did not differ between cycle phases at SL, but it was 3% higher during the midluteal phase with AA exposure. NeitherV\u02d9o<jats:sub>2 peak<\/jats:sub>nor Exh time was affected by cycle phase at SL or AA. We conclude that, despite significantly increased progesterone levels in the midluteal phase, exercise V\u02d9e is not increased at SL or AA. Moreover, neither maximal nor submaximal exercise performance is affected by menstrual cycle phase at SL or AA.<\/jats:p>","DOI":"10.1152\/jappl.1999.86.5.1519","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T14:11:27Z","timestamp":1513951887000},"page":"1519-1526","source":"Crossref","is-referenced-by-count":100,"title":["Exercise V\u02d9<scp>e<\/scp>and physical performance at altitude are not affected by menstrual cycle phase"],"prefix":"10.1152","volume":"86","author":[{"given":"Beth A.","family":"Beidleman","sequence":"first","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Rock","sequence":"additional","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Muza","sequence":"additional","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Fulco","sequence":"additional","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Vincent A.","family":"Forte","sequence":"additional","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Cymerman","sequence":"additional","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","first-page":"339","volume":"1","author":"Banderet L. 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