{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:23:52Z","timestamp":1788913432726,"version":"build-2803163510"},"reference-count":37,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,5,1]]},"abstract":" The effect of carbonic anhydrase inhibition with acetazolamide (Acz) on CO2<\/jats:sub> output (V\u02d9co 2<\/jats:sub>) and ventilation (V\u02d9e) kinetics was examined during moderate- and heavy-intensity exercise. Seven men [24 \u00b1 1 (SE) yr] performed cycling exercise during control (Con) and Acz (10 mg\/kg body wt iv) sessions. Each subject performed step transitions (6 min) in work rate from 0 to 100 W [below ventilatory threshold (<V\u02d9eT)] and to an O2<\/jats:sub> uptake corresponding to \u223c50% of the difference between the work rate atV\u02d9eT and peak O2<\/jats:sub> uptake [above ventilatory threshold (>V\u02d9eT)].V\u02d9e and gas exchange were measured breath by breath. The time constant (\u03c4) was determined for exercise <V\u02d9eT by using a single-exponential model (fit between 20 s and end-exercise); the mean response time (MRT) was determined for exercise >V\u02d9eT by using a three-component model (fit from the start of exercise).V\u02d9co 2<\/jats:sub> kinetics were slower in Acz (<V\u02d9eT, \u03c4 = 45 \u00b1 6 s; >V\u02d9eT, MRT = 75 \u00b1 10 s) than Con (<V\u02d9eT, \u03c4 = 34 \u00b1 6 s; >V\u02d9eT, MRT = 54 \u00b1 7 s). During <V\u02d9eT exercise,V\u02d9e kinetics were slower in Acz (\u03c4 = 48 \u00b1 6 s) than Con (\u03c4 = 34 \u00b1 6 s), but >V\u02d9eT kinetics were faster in Acz (MRT = 85 \u00b1 17 s) than Con (MRT = 106 \u00b1 16 s). Carbonic anhydrase inhibition slowedV\u02d9co 2<\/jats:sub> kinetics during both moderate- and heavy-intensity exercise, demonstrating impaired CO2<\/jats:sub> elimination in the nonsteady state of exercise. The slowedV\u02d9e kinetics in Acz during exercise <V\u02d9eT is consistent with a mechanism coupling V\u02d9e kinetics with the flow of CO2<\/jats:sub> to the lungs. <\/jats:p>","DOI":"10.1152\/jappl.1999.86.5.1534","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T14:11:27Z","timestamp":1513951887000},"page":"1534-1543","source":"Crossref","is-referenced-by-count":19,"title":["V\u02d9co<\/scp> 2<\/sub> andV\u02d9e<\/scp> kinetics during moderate- and heavyintensity exercise after acetazolamide administration"],"prefix":"10.1152","volume":"86","author":[{"given":"Barry W.","family":"Scheuermann","sequence":"first","affiliation":[{"name":"The Centre for Activity and Ageing, School of Kinesiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Kowalchuk","sequence":"additional","affiliation":[{"name":"The Centre for Activity and Ageing, School of Kinesiology, and"},{"name":"Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald H.","family":"Paterson","sequence":"additional","affiliation":[{"name":"The Centre for Activity and Ageing, School of Kinesiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"The Centre for Activity and Ageing, School of Kinesiology, and"},{"name":"Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.6.1662"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-84-20587"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.4.1686"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.45.4.565"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.41.6.886"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1961.16.6.1023"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.2.683"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.2.547"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(84)90064-1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016292"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(95)00009-3"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.261.4.C565"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.4.1587"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.1.278"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.3.1211"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111112852002"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1967.47.4.595"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.4.1013"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018894"},{"key":"B20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1152\/ajplegacy.1941.135.1.77","volume":"135","author":"Roughton F. 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