{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:09:58Z","timestamp":1774566598790,"version":"3.50.1"},"reference-count":27,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:p>The effect of carbonic anhydrase inhibition with acetazolamide (Acz, 10 mg\/kg) on the ventilatory response to an abrupt switch into hyperoxia (end-tidal [Formula: see text]= 450 Torr) and hypoxia (end-tidal[Formula: see text] = 50 Torr) was examined in five male subjects [30 \u00b1 3 (SE) yr]. Subjects exercised at a work rate chosen to elicit an O<jats:sub>2<\/jats:sub>uptake equivalent to 80% of the ventilatory threshold. Ventilation (V\u02d9e) was measured breath by breath. Arterial oxyhemoglobin saturation (%[Formula: see text]) was determined by ear oximetry. After the switch into hyperoxia, V\u02d9eremained unchanged from the steady-state exercise prehyperoxic value (60.6 \u00b1 6.5 l\/min) during Acz. During control studies (Con),V\u02d9e decreased from the prehyperoxic value (52.4 \u00b1 5.5 l\/min) by \u223c20% (V\u02d9enadir = 42.4 \u00b1 6.3 l\/min) within 20 s after the switch into hyperoxia. V\u02d9e increased during Acz and Con after the switch into hypoxia; the hypoxic ventilatory response was significantly lower after Acz compared with Con [Acz, change (\u0394) inV\u02d9e\/[Formula: see text]= 1.54 \u00b1 0.10 l \u22c5 min<jats:sup>\u22121<\/jats:sup>\u22c5 [Formula: see text]<jats:sup>\u22121<\/jats:sup>; Con, \u0394V\u02d9e\/[Formula: see text]= 2.22 \u00b1 0.28 l \u22c5 min<jats:sup>\u22121<\/jats:sup>\u22c5 [Formula: see text]<jats:sup>\u22121<\/jats:sup>]. The peripheral chemoreceptor contribution to the ventilatory drive after acute Acz-induced carbonic anhydrase inhibition is not apparent in the steady state of moderate-intensity exercise. However, Acz administration did not completely attenuate the peripheral chemoreceptor response to hypoxia.<\/jats:p>","DOI":"10.1152\/jappl.1999.86.5.1544","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T14:11:27Z","timestamp":1513951887000},"page":"1544-1551","source":"Crossref","is-referenced-by-count":10,"title":["Peripheral chemoreceptor function after carbonic anhydrase inhibition during moderate-intensity exercise"],"prefix":"10.1152","volume":"86","author":[{"given":"Barry W.","family":"Scheuermann","sequence":"first","affiliation":[{"name":"Centre for Activity and Ageing, School of Kinesiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Kowalchuk","sequence":"additional","affiliation":[{"name":"Centre for Activity and Ageing, School of Kinesiology, and"},{"name":"Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald H.","family":"Paterson","sequence":"additional","affiliation":[{"name":"Centre for Activity and Ageing, School of Kinesiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Centre for Activity and Ageing, School of Kinesiology, and"},{"name":"Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1961.16.6.1023"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1962.42.3.335"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1962.tb11859.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016292"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.1.278"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.3.1211"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1159\/000458029"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.38.607"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1139\/h97-003"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00489979"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.5.1358"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.5.1534"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4809(89)90006-2"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1139\/h96-025"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.1.230"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(78)90018-X"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(88)90044-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.36.511"},{"key":"B21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3565(25)28985-6","volume":"178","author":"Travis D. 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