{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:16:46Z","timestamp":1774567006969,"version":"3.50.1"},"reference-count":20,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,6,1]]},"abstract":"<jats:p>The fraction of an inspired chlorine (Cl<jats:sub>2<\/jats:sub>) bolus absorbed during a single breath (\u039b) was measured as a function of bolus penetration (V<jats:sub>P<\/jats:sub>) into the respiratory system of five male and five female nonsmokers during both nasal and oral breathing at a quiet respiratory flow of 250 ml\/s. The correspondence between V<jats:sub>P<\/jats:sub>and specific anatomic landmarks was found for each subject by a combination of acoustic reflection and nitrogen washout measurements. For both nasal and oral breathing, \u039b reached \u223c0.95 at the distal end of the upper airways and reached 1.00 within the lower conducting airways. The values of a regional mass transfer parameter computed from the \u039b-V<jats:sub>P<\/jats:sub>data indicated that the resistance to Cl<jats:sub>2<\/jats:sub>diffusion in the airway mucosa was negligible compared with the diffusion resistance in the respired gas. Changing the peak inhaled Cl<jats:sub>2<\/jats:sub>concentration from 0.5 to 3.0 parts\/million did not significantly affect the distribution of Cl<jats:sub>2<\/jats:sub>absorption, suggesting that the underlying mass transport and chemical reaction processes were linear with respect to Cl<jats:sub>2<\/jats:sub>concentration.<\/jats:p>","DOI":"10.1152\/jappl.1999.86.6.1984","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T13:55:22Z","timestamp":1513950922000},"page":"1984-1993","source":"Crossref","is-referenced-by-count":28,"title":["Longitudinal distribution of chlorine absorption in human airways: comparison of nasal and oral quiet breathing"],"prefix":"10.1152","volume":"86","author":[{"given":"Vladislav","family":"Nodelman","sequence":"first","affiliation":[{"name":"Biological Transport Dynamics Laboratory, Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Ultman","sequence":"additional","affiliation":[{"name":"Biological Transport Dynamics Laboratory, Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.127.1.39"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.4.1651"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1975.10666702"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.48.5.749"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.4.1655"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.2.574"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.6.2584"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(87)90037-6"},{"key":"B12","first-page":"587","volume":"113","author":"Knudsen R. J.","year":"1976","journal-title":"Am. Rev. Respir. Dis."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/3.6.225"},{"key":"B14","first-page":"199","volume":"88","author":"Matthews L. W.","year":"1963","journal-title":"Am. Rev. Respir. Dis."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(83)90232-1"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1080\/00984109708984003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/33.7.405"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1063\/1.1149208"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1973.00320070047005"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.4.1120"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1021\/ie50378a014"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1995.1013"},{"key":"B29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1542\/peds.79.3.427","volume":"79","author":"Wood B. R.","year":"1987","journal-title":"Pediatrics"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1999.86.6.1984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T02:32:14Z","timestamp":1660185134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1999.86.6.1984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,1]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,6,1]]}},"alternative-id":["10.1152\/jappl.1999.86.6.1984"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1999.86.6.1984","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6,1]]}}}