{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:09:45Z","timestamp":1785802185398,"version":"3.56.0"},"reference-count":32,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,8,1]]},"abstract":"<jats:p> Previous work has shown that the magnitude of state-related ventilatory fluctuations is amplified over the sleep-onset period and that this amplification is partly due to peripheral chemoreceptor activity, because it is reduced by hyperoxia (J. Dunai, M. Wilkinson, and J. Trinder. J. Appl. Physiol. 81: 2235\u20132243, 1996). These data also indicated considerable intersubject variability in the magnitude of amplification. A possible source of this variability is individual differences in peripheral chemoreceptor drive (PCD). We tested this hypothesis by measuring state-related ventilatory fluctuations throughout sleep onset under normoxic and hyperoxic conditions in subjects with high and low PCD. Results demonstrated that high-PCD subjects experienced significantly greater amplification of state-related ventilatory fluctuations than did low-PCD subjects. In addition, hyperoxia significantly reduced the amplification effect in high-PCD subjects but had little effect in low-PCD subjects. These results indicate that individuals with high PCD are likely to experience greater sleep-related ventilatory instability and suggest that peripheral chemoreceptor activity can contribute to sleep-disordered breathing. <\/jats:p>","DOI":"10.1152\/jappl.1999.87.2.661","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T15:40:36Z","timestamp":1513957236000},"page":"661-672","source":"Crossref","is-referenced-by-count":32,"title":["Ventilatory instability during sleep onset in individuals  with high peripheral chemosensitivity"],"prefix":"10.1152","volume":"87","author":[{"given":"Judith","family":"Dunai","sequence":"first","affiliation":[{"name":"Department of Psychology, School of Behavioural Science, University of Melbourne, Parkville, Victoria 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kleiman","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Behavioural Science, University of Melbourne, Parkville, Victoria 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Trinder","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Behavioural Science, University of Melbourne, Parkville, Victoria 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.2.696"},{"key":"B2","first-page":"632","volume":"125","author":"Berthon-Jones M.","year":"1982","journal-title":"Am. 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