{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:53:11Z","timestamp":1776703991152,"version":"3.51.2"},"reference-count":24,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,9,1]]},"abstract":"<jats:p> The effects of hypocapnia [arterial[Formula: see text]([Formula: see text]) 15 Torr] on splanchnic hemodynamics and gut mucosal-arterial[Formula: see text] were studied in seven anesthetized ventilated dogs. Ileal mucosal and serosal blood flow were estimated by using laser Doppler flowmetry, mucosal[Formula: see text] was measured continuously by using capnometric recirculating gas tonometry, and serosal surface[Formula: see text] was assessed by using a polarographic electrode. Hypocapnia was induced by removal of dead space and was maintained for 45 min, followed by 45 min of eucapnia. Mean [Formula: see text] at baseline was 38.1 \u00b1 1.1 (SE) Torr and decreased to 13.8 \u00b1 1.3 Torr after removal of dead space. Cardiac output and portal blood flow decreased significantly with hypocapnia. Similarly, mucosal and serosal blood flow decreased by 15 \u00b1 4 and by 34 \u00b1 7%, respectively. Also, an increase in the mucosal-arterial[Formula: see text] gradient of 10.7 Torr and a reduction in serosal [Formula: see text] of 30 Torr were observed with hypocapnia ( P &lt; 0.01 for both). Hypocapnia caused ileal mucosal and serosal hypoperfusion, with redistribution of flow favoring the mucosa, accompanied by increased [Formula: see text]gradient and diminished serosal [Formula: see text]. <\/jats:p>","DOI":"10.1152\/jappl.1999.87.3.1102","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T10:18:18Z","timestamp":1513937898000},"page":"1102-1106","source":"Crossref","is-referenced-by-count":20,"title":["Splanchnic hemodynamics and gut mucosal-arterial   P  CO  2     gradient during systemic hypocapnia"],"prefix":"10.1152","volume":"87","author":[{"given":"Jorge A.","family":"Guzman","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Kruse","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"issue":"22","key":"B1","first-page":"G519","volume":"259","author":"Antonsson J. 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