{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:47:29Z","timestamp":1791118049166,"version":"4.1.0"},"reference-count":21,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1999,12,1]]},"abstract":"<jats:p> Oxygen free radicals are highly reactive species that are produced in increased quantities during strenuous exercise and can damage critical biological targets such as membrane phospholipids. The present study examined the effect of acute ascorbic acid supplementation on exercise-induced free radical production in healthy subjects. Results demonstrate increases in the intensity of the \u03b1-phenyl- tert-butylnitrone adduct (0.05 \u00b1 0.02 preexercise vs. 0.19 \u00b1 0.03 postexercise, P = 0.002, arbitrary units) together with increased lipid hydroperoxides (1.14 \u00b1 0.06 \u03bcmol\/l preexercise vs. 1.62 \u00b1 0.19 \u03bcmol\/l postexercise, P = 0.005) and malondialdehyde (0.70 \u00b1 0.04 \u03bcmol\/l preexercise vs. 0.80 \u00b1 0.04 \u03bcmol\/l postexercise, P = 0.0152) in the control phase. After supplementation with ascorbic acid, there was no significant increase in the electron spin resonance signal intensity (0.02 \u00b1 0.01 preexercise vs. 0.04 \u00b1 0.02 postexercise, arbitrary units), lipid hydroperoxides (1.12 \u00b1 0.21 \u03bcmol\/l preexercise vs. 1.12 \u00b1 0.08 \u03bcmol\/l postexercise), or malondialdehyde (0.63 \u00b1 0.07 \u03bcmol\/l preexercise vs. 0.68 \u00b1 0.05 \u03bcmol\/l postexercise). The results indicate that acute ascorbic acid supplementation prevented exercise-induced oxidative stress in these subjects. <\/jats:p>","DOI":"10.1152\/jappl.1999.87.6.2032","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T16:43:05Z","timestamp":1513960985000},"page":"2032-2036","source":"Crossref","is-referenced-by-count":104,"title":["Electron spin resonance spectroscopy, exercise,  and oxidative stress: an ascorbic acid intervention study"],"prefix":"10.1152","volume":"87","author":[{"given":"Tony","family":"Ashton","sequence":"first","affiliation":[{"name":"School of Applied Sciences, University of Glamorgan, Pontypridd, Wales, CF37 1DL;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Institute of Clinical Science, Queens University, Belfast, Northern Ireland, BT12 6BL;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital of Wales, Cardiff, Wales, CF4 4XW;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleri","family":"Jones","sequence":"additional","affiliation":[{"name":"University of Wales Institute Cardiff, Cardiff, Wales, CF3 7XR;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon K.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Section of Immunology, University of Wales College of Medicine, Cardiff, Wales, CF4 4XN; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Davies","sequence":"additional","affiliation":[{"name":"School of Applied Sciences, University of Glamorgan, Pontypridd, Wales, CF37 1DL;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowlands","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National EPSRC ENDOR Centre, Cardiff University, Cardiff, Wales, CF1 3TB, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1123\/ijsn.7.1.1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050366"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S8755-9668(86)80021-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(82)80124-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6377"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9748"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.61.5.757"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972864"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90091-V"},{"key":"B11","first-page":"27","volume":"63","author":"Mulholland C. 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