{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:45:04Z","timestamp":1787067904051,"version":"build-2736575974"},"reference-count":20,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"\n We measured the effect of thoracoabdominal configuration on twitch transdiaphragmatic pressure (Pdi, t) in response to supramaximal, transcutaneous, bilateral phrenic nerve shocks in three thin normal men. Pdi, t was measured as a function of lung volume (Vl) in the relaxation configuration, at functional residual capacity (FRC), and at the same end-tidal Vl 1) during relaxation; 2) with the abdomen (Ab) expanded and the rib cage (RC) in its relaxed FRC configuration; 3) with RC expanded and Ab in its relaxed FRC configuration; and 4) in configuration 3 with an active transdiaphragmatic pressure similar to that required to produce configuration 2. In increasing Vl from FRC to configuration 1, Pdi, t decreased by 3.6 cmH\n 2<\/jats:sub>\n O; to configuration 2 by 14.8 cmH\n 2<\/jats:sub>\n O; to configuration 3 by 3.7 cmH\n 2<\/jats:sub>\n O; and to configuration 4 by 2.7 cmH\n 2<\/jats:sub>\n O. We argue that changes in velocity of shortening and radius of curvature are unlikely to account for these effects and suggest that changes in diaphragmatic fiber length ( L\n di<\/jats:sub>\n ) are primarily responsible. If so, equivolume displacements of Ab and RC change L\n di<\/jats:sub>\n in a ratio of \u223c4:1. We conclude that Pdi, t is exquisitely sensitive to abdominal displacements that must be rigorously controlled if Pdi, t is to be used to assess diaphragmatic contractility.\n <\/jats:p>","DOI":"10.1152\/jappl.2000.88.1.54","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T11:26:03Z","timestamp":1513941963000},"page":"54-60","source":"Crossref","is-referenced-by-count":24,"title":["Twitch transdiaphragmatic pressure depends critically on thoracoabdominal configuration"],"prefix":"10.1152","volume":"88","author":[{"given":"Rongchang","family":"Chen","sequence":"first","affiliation":[{"name":"Meakins-Christie Laboratories, Montreal Chest Institute, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H2X 2P4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Kayser","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Montreal Chest Institute, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H2X 2P4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Montreal Chest Institute, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H2X 2P4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Macklem","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Montreal Chest Institute, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H2X 2P4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","first-page":"A417","volume":"159","author":"Aliverti A.","year":"1999","journal-title":"Am. 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