{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:27:12Z","timestamp":1791322032079,"version":"4.3.1"},"reference-count":19,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:p> We sought to investigate further the roles of sweating, ACh spillover, and nitric oxide (NO) in the neurally mediated cutaneous vasodilation during body heating in humans. Six subjects were heated with a water-perfused suit while cutaneous blood flow was measured with a laser-Doppler flowmeter. After a rise in core temperature (1.0 \u00b1 0.1\u00b0C) and the establishment of cutaneous vasodilation, atropine and subsequently the NO synthase inhibitor N <jats:sup>G<\/jats:sup>-nitro-l-arginine methyl ester (l-NAME) were given to the forearm via a brachial artery catheter. After atropine infusion, cutaneous vascular conductance (CVC) remained constant in five of six subjects, whereasl-NAME administration blunted the rise in CVC in three of six subjects. A subsequent set of studies using intradermal microdialysis probes to selectively deliver drugs into forearm skin confirmed that atropine did not affect CVC. However, perfusion ofl-NAME resulted in a significant decrease in CVC (37 \u00b1 4%, P &lt; 0.05). The results indicate that neither sweating nor NO release via muscarinic receptor activation is essential to sustain cutaneous dilation during heating in humans. <\/jats:p>","DOI":"10.1152\/jappl.2000.88.2.467","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T11:34:12Z","timestamp":1513942452000},"page":"467-472","source":"Crossref","is-referenced-by-count":98,"title":["Effects of atropine and <scp>l<\/scp>-NAME on cutaneous blood flow  during body heating in humans"],"prefix":"10.1152","volume":"88","author":[{"given":"Shubha","family":"Shastry","sequence":"first","affiliation":[{"name":"Departments of Physiology and Biophysics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Minson","sequence":"additional","affiliation":[{"name":"Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurea A.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki M.","family":"Dietz","sequence":"additional","affiliation":[{"name":"Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Joyner","sequence":"additional","affiliation":[{"name":"Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020366"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.5.2047"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.4.1807"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.269.5.H1613"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.272.3.R975"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1958.sp006011"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.3.798"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.6.1785"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.3.824"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.4.1185"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.6.1222"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00586536"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.270.2.H442"},{"key":"B14","first-page":"H242","volume":"160","author":"Mugge A.","year":"1991","journal-title":"Am. 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