{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:47:04Z","timestamp":1785167224388,"version":"3.55.0"},"reference-count":36,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:p> This paper describes and quantifies acute responses of the kidneys in correcting plasma volume, acid-base, and ion disturbances resulting from NaHCO<jats:sub>3<\/jats:sub> and KHCO<jats:sub>3<\/jats:sub> ingestion. Renal excretion of ions and water was studied in five men after ingestion of 3.57 mmol\/kg body mass of sodium bicarbonate (NaHCO<jats:sub>3<\/jats:sub>) and, in a separate trial, potassium bicarbonate (KHCO<jats:sub>3<\/jats:sub>). Subjects had a Foley catheter inserted into the bladder and indwelling catheters placed into an antecubital vein and a brachial artery. Blood and urine were sampled in the 30-min period before, the 60-min period during, and the 210-min period after ingestion of the solutions. NaHCO<jats:sub>3<\/jats:sub> ingestion resulted in a rapid, transient diuresis and natriuresis. Cumulative urine output was 44 \u00b1 11% of ingested volume, resulting in a 555 \u00b1 119 ml increase in total body water at the end of the experiment. The cumulative increase (above basal levels) in renal Na<jats:sup>+<\/jats:sup> excretion accounted for 24 \u00b1 2% of ingested Na<jats:sup>+<\/jats:sup>. In the KHCO<jats:sub>3<\/jats:sub> trial, arterial plasma K<jats:sup>+<\/jats:sup> concentration rapidly increased from 4.25 \u00b1 0.10 to a peak of 7.17 \u00b1 0.13 meq\/l 140 min after the beginning of ingestion. This increase resulted in a pronounced, transient diuresis, with cumulative urine output at 270 min similar to the volume ingested, natriuresis, and a pronounced kaliuresis that was maintained until the end of the experiment. Cumulative (above basal) renal K<jats:sup>+<\/jats:sup> excretion at 270 min accounted for 26 \u00b1 5% of ingested K<jats:sup>+<\/jats:sup>. The kidneys were important in mediating rapid corrections of substantial portions of the fluid and electrolyte disturbances resulting from ingestion of KHCO<jats:sub>3<\/jats:sub> and NaHCO<jats:sub>3<\/jats:sub> solutions. <\/jats:p>","DOI":"10.1152\/jappl.2000.88.2.540","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T16:34:12Z","timestamp":1513960452000},"page":"540-550","source":"Crossref","is-referenced-by-count":47,"title":["NaHCO<sub>3<\/sub> and KHCO<sub>3<\/sub> ingestion rapidly increases  renal electrolyte excretion in humans"],"prefix":"10.1152","volume":"88","author":[{"given":"Michael I.","family":"Lindinger","sequence":"first","affiliation":[{"name":"Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph N1G 2W1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph N1G 2W1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry C.","family":"Lands","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preben K.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Physical Education, University of Odense, DK 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald G.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph N1G 2W1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J. 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