{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:11Z","timestamp":1777493531211,"version":"3.51.4"},"reference-count":23,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:p> The effect of carbonic anhydrase (CA) inhibition with acetazolamide (Acz, 10 mg\/kg body wt iv) on exercise performance and the ventilatory (V\u02d9eT) and lactate (LaT) thresholds was studied in seven men during ramp exercise (25 W\/min) to exhaustion. Breath-by-breath measurements of gas exchange were obtained. Arterialized venous blood was sampled from a dorsal hand vein and analyzed for plasma pH,[Formula: see text], and lactate concentration ([La<jats:sup>\u2212<\/jats:sup>]<jats:sub>pl<\/jats:sub>).V\u02d9eT [expressed as O<jats:sub>2<\/jats:sub> uptake (V\u02d9o <jats:sub>2<\/jats:sub>), ml\/min] was determined using the V-slope method. LaT (expressed asV\u02d9o <jats:sub>2<\/jats:sub>, ml\/min) was determined from the work rate (WR) at which [La<jats:sup>\u2212<\/jats:sup>]<jats:sub>pl<\/jats:sub>increased 1.0 mM above rest levels. Peak WR was higher in control (Con) than in Acz sutdies [339 \u00b1 14 vs. 315 \u00b1 14 (SE) W]. Submaximal exercise V\u02d9o <jats:sub>2<\/jats:sub> was similar in Acz and Con; the lowerV\u02d9o <jats:sub>2<\/jats:sub> at exhaustion in Acz than in Con (3.824 \u00b1 0.150 vs. 4.283 \u00b1 0.148 l\/min) was appropriate for the lower WR. CO<jats:sub>2<\/jats:sub>output (V\u02d9co <jats:sub>2<\/jats:sub>) was lower in Acz than in Con at exercise intensities \u2265125 W and at exhaustion (4.375 \u00b1 0.158 vs. 5.235 \u00b1 0.148 l\/min). [La<jats:sup>\u2212<\/jats:sup>]<jats:sub>pl<\/jats:sub>was lower in Acz than in Con during submaximal exercise \u2265150 W and at exhaustion (7.5 \u00b1 1.1 vs. 11.5 \u00b1 1.1 mmol\/l).V\u02d9eT was similar in Acz and Con (2.483 \u00b1 0.086 and 2.362 \u00b1 0.110 l\/min, respectively), whereas the LaT occurred at a higherV\u02d9o <jats:sub>2<\/jats:sub> in Acz than in Con (2.738 \u00b1 0.223 vs. 2.190 \u00b1 0.235 l\/min). CA inhibition with Acz is associated with impaired elimination of CO<jats:sub>2<\/jats:sub> during the non-steady-state condition of ramp exercise. The similarity inV\u02d9eT in Con and Acz suggests that La<jats:sup>\u2212<\/jats:sup>production is similar between conditions but La<jats:sup>\u2212<\/jats:sup> appearance in plasma is reduced and\/or La<jats:sup>\u2212<\/jats:sup> uptake by other tissues is enhanced after the Acz treatment. <\/jats:p>","DOI":"10.1152\/jappl.2000.88.2.713","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T16:34:12Z","timestamp":1513960452000},"page":"713-721","source":"Crossref","is-referenced-by-count":13,"title":["Carbonic anhydrase inhibition delays plasma lactate  appearance with no effect on ventilatory threshold"],"prefix":"10.1152","volume":"88","author":[{"given":"Barry W.","family":"Scheuermann","sequence":"first","affiliation":[{"name":"Centre for Activity and Ageing, School of Kinesiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Kowalchuk","sequence":"additional","affiliation":[{"name":"Centre for Activity and Ageing, School of Kinesiology, and"},{"name":"Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald H.","family":"Paterson","sequence":"additional","affiliation":[{"name":"Centre for Activity and Ageing, School of Kinesiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Centre for Activity and Ageing, School of Kinesiology, and"},{"name":"Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.6.1662"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199104000-00012"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198502000-00005"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198502000-00003"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.3.999"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972995"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.6.1598"},{"key":"B8","first-page":"A171","volume":"155","author":"Korotzer B.","year":"1997","journal-title":"Am. 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