{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:59:15Z","timestamp":1791194355831,"version":"4.1.0"},"reference-count":28,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:p>We hypothesized that abnormal endothelium-dependent vasodilation (EDD) found in older otherwise healthy subjects can be attenuated with long-term endurance training. Ten endurance-trained men, 68.5 \u00b1 2.3 yr old, and 10 healthy sedentary men, 64.7 \u00b1 1.4 yr old, were studied. Aerobic exercise capacity (V\u02d9o<jats:sub>2 max<\/jats:sub>), fasting plasma cholesterol, insulin, and homocysteine concentrations were measured. Master athletes had higherV\u02d9o<jats:sub>2 max<\/jats:sub>(42 \u00b1 2.3 vs. 27 \u00b1 1.4 ml \u22c5 kg<jats:sup>\u2212<\/jats:sup><jats:sup>1<\/jats:sup>\u22c5 min<jats:sup>\u2212<\/jats:sup><jats:sup>1<\/jats:sup>, P &lt; 0.001), slightly higher total cholesterol (226 \u00b1 8 vs. 199 \u00b1 8 mg\/dl, P = 0.05), similar insulin, and higher homocysteine (10.7 \u00b1 1.3 vs. 9.2 \u00b1 1.4 \u03bcmol\/ml, p= 0.02) concentrations. Brachial arterial diameter, determined with vascular ultrasound, during the hyperemic response was greater in the master athletes than in controls ( P = 0.005). Peak vasodilatory response was 109.1 \u00b1 2 vs. 103.6 \u00b1 2% ( P &lt; 0.05) in the athletes and controls, respectively. Endothelium-independent vasodilation in response to nitroglycerin was similar between the two groups. The increased arterial diameter during the hyperemic response correlated significantly with theV\u02d9o<jats:sub>2 max<\/jats:sub>in the entire population ( r = 0.66, P &lt; 0.002). Our results suggest that long-term endurance exercise training in older men is associated with systemic enhanced EDD, which is even detectable in the conduit arteries of untrained muscle.<\/jats:p>","DOI":"10.1152\/jappl.2000.88.2.761","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T16:34:12Z","timestamp":1513960452000},"page":"761-766","source":"Crossref","is-referenced-by-count":83,"title":["Enhanced endothelium-dependent vasodilation in older endurance-trained men"],"prefix":"10.1152","volume":"88","author":[{"given":"Morton R.","family":"Rinder","sequence":"first","affiliation":[{"name":"Division of Gerontology and Geriatrics and Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Spina","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatrics and Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Ehsani","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatrics and Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502233320802"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(87)80438-3"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00189-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.268.4.H1397"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.6.2886"},{"key":"B6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"Friedewald W. 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