{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:47:19Z","timestamp":1775742439639,"version":"3.50.1"},"reference-count":57,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,5,1]]},"abstract":"<jats:p>This study examined the effects of preexercise glucose administration, with and without epinephrine infusion, on carbohydrate metabolism in horses during exercise. Six horses completed 60 min of treadmill exercise at 55 \u00b1 1% maximum O<jats:sub>2<\/jats:sub>uptake 1) 1 h after oral administration of glucose (2 g\/kg; G trial); 2) 1 h after oral glucose and with an intravenous infusion of epinephrine (0.2 \u03bcmol \u22c5 kg<jats:sup>\u2212<\/jats:sup><jats:sup>1<\/jats:sup>\u22c5 min<jats:sup>\u2212<\/jats:sup><jats:sup>1<\/jats:sup>; GE trial) during exercise, and 3) 1 h after water only (F trial). Glucose administration (G and GE) caused hyperinsulinemia and hyperglycemia (\u223c8 mM). In GE, plasma epinephrine concentrations were three- to fourfold higher than in the other trials. Compared with F, the glucose rate of appearance was \u223c50% and \u223c33% higher in G and GE, respectively, during exercise. The glucose rate of disappearance was \u223c100% higher in G than in F, but epinephrine infusion completely inhibited the increase in glucose uptake associated with glucose administration. Muscle glycogen utilization was higher in GE [349 \u00b1 44 mmol\/kg dry muscle (dm)] than in F (218 \u00b1 28 mmol\/kg dm) and G (201 \u00b1 35 mmol\/kg dm). We conclude that 1) preexercise glucose augments utilization of plasma glucose in horses during moderate-intensity exercise but does not alter muscle glycogen usage and 2) increased circulating epinephrine inhibits the increase in glucose rate of disappearance associated with preexercise glucose administration and increases reliance on muscle glycogen for energy transduction.<\/jats:p>","DOI":"10.1152\/jappl.2000.88.5.1777","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T00:45:55Z","timestamp":1513989955000},"page":"1777-1790","source":"Crossref","is-referenced-by-count":32,"title":["Epinephrine inhibits exogenous glucose utilization in exercising horses"],"prefix":"10.1152","volume":"88","author":[{"given":"Raymond J.","family":"Geor","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 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