{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:05:14Z","timestamp":1790384714475,"version":"4.1.0"},"reference-count":27,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"\n We hypothesize that plasma volume decrease (\u0394PV) induced by high-altitude (HA) exposure and intense exercise is involved in the limitation of maximal O\n 2<\/jats:sub>\n uptake (V\u02d9o\n 2<\/jats:sub>\n max<\/jats:sub>\n ) at HA. Eight male subjects were decompressed for 31 days in a hypobaric chamber to the barometric equivalent of Mt. Everest (8,848 m). Maximal exercise was performed with and without plasma volume expansion (PVX, 219\u2013292 ml) during exercise, at sea level (SL), at HA (370 mmHg, equivalent to 6,000 m after 10\u201312 days) and after return to SL (RSL, 1\u20133 days). Plasma volume (PV) was determined at rest at SL, HA, and RSL by Evans blue dilution. PV was decreased by 26% ( P < 0.01) at HA and was 10% higher at RSL than at SL. Exercise-induced \u0394PV was reduced both by PVX and HA ( P < 0.05). Compared with SL, V\u02d9o\n 2<\/jats:sub>\n max<\/jats:sub>\n was decreased by 58 and 11% at HA and RSL, respectively.V\u02d9o\n 2<\/jats:sub>\n max<\/jats:sub>\n was enhanced by PVX at HA (+9%, P < 0.05) but not at SL or RSL. The more PV was decreased at HA, the moreV\u02d9o\n 2<\/jats:sub>\n max<\/jats:sub>\n was improved by PVX ( P < 0.05). At exhaustion, plasma renin and aldosterone were not modified at HA compared with SL but were higher at RSL, whereas plasma atrial natriuretic factor was lower at HA. The present results suggest that PV contributes to the limitation ofV\u02d9o\n 2<\/jats:sub>\n max<\/jats:sub>\n during acclimatization to HA. RSL-induced PVX, which may be due to increased activity of the renin-aldosterone system, could also influence the recovery ofV\u02d9o\n 2<\/jats:sub>\n max<\/jats:sub>\n .\n <\/jats:p>","DOI":"10.1152\/jappl.2000.89.1.29","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:59:59Z","timestamp":1513976399000},"page":"29-37","source":"Crossref","is-referenced-by-count":58,"title":["Operation Everest III: role of plasma volume expansion onV\u02d9\n \n o\n 2<\/sub>\n <\/scp>\n max<\/sub>\n during prolonged high-altitude exposure"],"prefix":"10.1152","volume":"89","author":[{"given":"Paul","family":"Robach","sequence":"first","affiliation":[{"name":"Ecole Nationale de Ski et d'alpinisme, 74401 Chamonix;"},{"name":"Association pour la Recherche en Physiologie de l'Environnement, 93017 Bobigny;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"D\u00e9chaux","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie, h\u00f4pital Necker, 75015 Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Jarrot","sequence":"additional","affiliation":[{"name":"Association pour la Recherche en Physiologie de l'Environnement, 93017 Bobigny;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Vaysse","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie, h\u00f4pital Jean Verdier, 93140 Bondy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Schneider","sequence":"additional","affiliation":[{"name":"Association pour la Recherche en Physiologie de l'Environnement, 93017 Bobigny;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Mason","sequence":"additional","affiliation":[{"name":"Association pour la Recherche en Physiologie de l'Environnement, 93017 Bobigny;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Herry","sequence":"additional","affiliation":[{"name":"Ecole Nationale de Ski et d'alpinisme, 74401 Chamonix;"},{"name":"Association pour la Recherche en Physiologie de l'Environnement, 93017 Bobigny;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Gardette","sequence":"additional","affiliation":[{"name":"COMEX S.A., 13275 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Richalet","sequence":"additional","affiliation":[{"name":"Association pour la Recherche en Physiologie de l'Environnement, 93017 Bobigny;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.1.141"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1024774"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.5.2446"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.44.5.652"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050331"},{"key":"B6","first-page":"1178","volume":"28","author":"Hannon JP","year":"1969","journal-title":"Fed Proc"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.5.1922"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1985.65.1.149"},{"key":"B10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1183\/09031936.93.03040465","volume":"3","author":"Huszczuk A","year":"1990","journal-title":"Eur Respir J"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.5.1186"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198406000-00010"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1972.tb05259.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.4.1180"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1964.sp007335"},{"key":"B18","first-page":"135","volume":"15","author":"Richalet J-P","year":"1995","journal-title":"Jap J Mountain Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92208-0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.6.1897"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.6.2545"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.1996.10608849"},{"key":"B25","first-page":"313","volume":"57","author":"Sarnquist FH","year":"1986","journal-title":"Aviat Space Environ Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.2.636"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.4.1309"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1992.263.3.R647"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.58.030196.000321"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.3.688"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.1.252"},{"key":"B32","first-page":"570","volume":"83","author":"Zaccaria M","year":"1998","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.2000.89.1.29","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T01:29:43Z","timestamp":1693358983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.2000.89.1.29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,7,1]]}},"alternative-id":["10.1152\/jappl.2000.89.1.29"],"URL":"https:\/\/doi.org\/10.1152\/jappl.2000.89.1.29","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7,1]]}}}