{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:16:58Z","timestamp":1773757018238,"version":"3.50.1"},"reference-count":39,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:p>Positive airway pressure (Paw) during high-frequency oscillatory ventilation (HFOV) increases lung volume and can lead to lung overdistention with potentially serious adverse effects. To date, no method is available to monitor changes in lung volume (\u0394Vl) in HFOV-treated infants to avoid overdistention. In five newborn piglets (6\u201315 days old, 2.2\u20134.2 kg), we investigated the use of direct current-coupled respiratory inductive plethysmography (RIP) for this purpose by evaluating it against whole body plethysmography. Animals were instrumented, fitted with RIP bands, paralyzed, sedated, and placed in the plethysmograph. RIP and plethysmography were simultaneously calibrated, and HFOV was instituted at varying Paw settings before (6\u201314 cmH<jats:sub>2<\/jats:sub>O) and after (10\u201324 cmH<jats:sub>2<\/jats:sub>O) repeated warm saline lung lavage to induce experimental surfactant deficiency. Estimates of \u0394Vl from both methods were in good agreement, both transiently and in the steady state. Maximal changes in lung volume (\u0394Vl<jats:sub>max<\/jats:sub>) from all piglets were highly correlated with \u0394Vl measured by RIP (in ml) = 1.01 \u00d7 changes measured by whole body plethysmography \u2212 0.35; r<jats:sup>2<\/jats:sup>= 0.95. Accuracy of RIP was unchanged after lavage. Effective respiratory system compliance (Ceff) decreased after lavage, yet it exhibited similar sigmoidal dependence on \u0394Vl<jats:sub>max<\/jats:sub>pre- and postlavage. A decrease in Ceff (relative to the previous Paw setting) as \u0394Vl<jats:sub>max<\/jats:sub>was methodically increased from low to high Paw provided a quantitative method for detecting lung overdistention. We conclude that RIP offers a noninvasive and clinically applicable method for accurately estimating lung recruitment during HFOV. Consequently, RIP allows the detection of lung overdistention and selection of optimal HFOV from derived Ceff data.<\/jats:p>","DOI":"10.1152\/jappl.2000.89.1.364","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T01:59:59Z","timestamp":1513994399000},"page":"364-372","source":"Crossref","is-referenced-by-count":23,"title":["Detecting lung overdistention in newborns treated with high-frequency oscillatory ventilation"],"prefix":"10.1152","volume":"89","author":[{"given":"Kaye","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Robert Wood Johnson Medical School at Camden, The Children's Regional Hospital at Cooper Hospital\/University Medical Center, Camden, New Jersey 08103; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry E.","family":"Courtney","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Robert Wood Johnson Medical School at Camden, The Children's 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