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During steady chemosensory excitation induced by hypoxia, bolus injections of NO (\u0394NO = 0.5\u201312 \u03bcM), released by S-nitroso- N-acetylpenicillamine (SNAP) and 6-(2-hydroxy-1-methyl-nitrosohydrazino)- N-methyl-1-hexanamine (NOC-9), transiently reduced \u0192<jats:sub>x<\/jats:sub>in a dose-dependent manner. However, during normoxia, the same concentration of NO (\u0394NO = 0.5\u201313 \u03bcM) released by the NO donors increased \u0192<jats:sub>x<\/jats:sub>in a dose-dependent manner. The present results show a dual effect of NO on CB chemoreception that is dependent on the Po<jats:sub>2<\/jats:sub>levels. During hypoxia, NO is predominantly an inhibitor of chemoreception, whereas, in normoxia, NO increased \u0192<jats:sub>x<\/jats:sub>. 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