{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:25:31Z","timestamp":1791156331489,"version":"4.1.0"},"reference-count":33,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,10,1]]},"abstract":"<jats:p> The effect of incremental exercise to exhaustion on the change in pulmonary clearance rate ( k) of aerosolized<jats:sup>99m<\/jats:sup>Tc-labeled diethylenetriaminepentaacetic acid (<jats:sup>99m<\/jats:sup>Tc-DTPA) and the relationship between k and arterial Po <jats:sub>2<\/jats:sub> (Pa<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub>) during heavy work were investigated. Ten male cyclists (age = 25 \u00b1 2 yr, height = 180.9 \u00b1 4.0 cm, mass = 80.1 \u00b1 9.5 kg, maximal O<jats:sub>2<\/jats:sub> uptake = 5.25 \u00b1 0.35 l\/min, mean \u00b1 SD) completed a pulmonary clearance test shortly (39 \u00b1 8 min) after a maximal O<jats:sub>2<\/jats:sub> uptake test. Resting pulmonary clearance was completed \u226524 h before or after the exercise test. Arterial blood was sampled at rest and at 1-min intervals during exercise. Minimum Pa<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub> values and maximum alveolar-arterial Po <jats:sub>2<\/jats:sub> difference ranged from 73 to 92 Torr and from 30 to 55 Torr, respectively. No significant difference between resting k and postexercise kfor the total lung (0.55 \u00b1 0.20 vs. 0.57 \u00b1 0.17 %\/min, P &gt; 0.05) was observed. Pearson product-moment correlation indicated no significant linear relationship between change in k for the total lung and minimum Pa<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub>( r = \u22120.26, P &gt; 0.05). These results indicate that, averaged over subjects, pulmonary clearance of<jats:sup>99m<\/jats:sup>Tc-DTPA after incremental maximal exercise to exhaustion in highly trained male cyclists is unchanged, although the sampling time may have eliminated a transient effect. Lack of a linear relationship between k and minimum Pa<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub>during exercise suggests that exercise-induced hypoxemia occurs despite maintenance of alveolar epithelial integrity. <\/jats:p>","DOI":"10.1152\/jappl.2000.89.4.1537","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T00:57:01Z","timestamp":1513990621000},"page":"1537-1542","source":"Crossref","is-referenced-by-count":21,"title":["Alveolar epithelial integrity in athletes with exercise-induced hypoxemia"],"prefix":"10.1152","volume":"89","author":[{"given":"Michael R.","family":"Edwards","sequence":"first","affiliation":[{"name":"Allan McGavin Sports Medicine Centre and School of Human Kinetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth S.","family":"Hunte","sequence":"additional","affiliation":[{"name":"Allan McGavin Sports Medicine Centre and School of Human Kinetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan S.","family":"Belzberg","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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