{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:51:59Z","timestamp":1761562319475},"reference-count":38,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:p> Diffusional permeability ( P) to inulin ( P <jats:sub>in<\/jats:sub>), albumin ( P <jats:sub>alb<\/jats:sub>), and dextrans [70 ( P <jats:sub>dx\u200970<\/jats:sub>), 150 ( P <jats:sub>dx\u2009150<\/jats:sub>), 550 ( P <jats:sub>dx\u2009550<\/jats:sub>), and 2,000 ( P <jats:sub>dx\u20092,000<\/jats:sub>)] was determined in specimens of parietal pericardium of rabbits, which may be obtained with less damage than pleura. P <jats:sub>in<\/jats:sub>, P <jats:sub>alb<\/jats:sub>, P <jats:sub>dx\u200970<\/jats:sub>, P <jats:sub>dx\u2009150<\/jats:sub>, P <jats:sub>dx\u2009550<\/jats:sub>, and P <jats:sub>dx\u20092,000<\/jats:sub> were 0.51 \u00b1 0.06 (SE), 0.18 \u00b1 0.03, 0.097 \u00b1 0.021, 0. 047 \u00b1 0.011, 0.025 \u00b1 0.004, and 0.021 \u00b1 0.005 \u00d7 10<jats:sup>\u22125<\/jats:sup>cm\/s, respectively. P <jats:sub>in<\/jats:sub>, P <jats:sub>alb<\/jats:sub>, and P <jats:sub>dx\u200970<\/jats:sub> of connective tissue, obtained after removal of mesothelium from specimens, were 10.3 \u00b1 1.42, 2.97 \u00b1 0.38, and 2.31 \u00b1 0.16 \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s, respectively. Hence, P <jats:sub>in<\/jats:sub>, P <jats:sub>alb<\/jats:sub>, and P <jats:sub>dx\u200970<\/jats:sub> of mesothelium were 0.54, 0.20, and 0.10 \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s, respectively. Inulin (like small solutes) fitted the relationship P-solute radius for restricted diffusion with a 6-nm \u201cpore\u201d radius, whereas macromolecules were much above it. Hence, macromolecule transfer mainly occurs through \u201clarge pores\u201d and\/or transcytosis. In line with this, the addition of phospholipids on the luminal side (which decreases pore radius to \u223c1.5 nm) halved P <jats:sub>in<\/jats:sub> but did not change P <jats:sub>alb<\/jats:sub>and P <jats:sub>dx\u200970<\/jats:sub>. P <jats:sub>in<\/jats:sub> is roughly similar in mesothelium and capillary endothelium, whereas P to macromolecules is greater in mesothelium. The albumin diffusion coefficient through connective tissue was 17% of that in water. 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