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Whereas 250 \u03bcl of aerosolized 0.9% saline caused a transient increase in RTFO, a 250-\u03bcl bumetanide-induced increase in RTFO was evident for 18 min and a 250-\u03bcl acetylstrophanthidin-induced increase in RTFO persisted for at least 30 min. Dry air ventilation decreased the responses of RTFO to the saline (sham) and acetylstrophanthidin intervention but not the bumetanide intervention. Delivery of 250 mosmol\/kgH<jats:sub>2<\/jats:sub>O ion-free mannitol (250 \u03bcl) caused marked increases in RTFO that were little affected by the administration of acetylstrophanthidin or bumetanide 30 min before these challenges. A 250-\u03bcl 550 mosmol\/kgH<jats:sub>2<\/jats:sub>O ion-free mannitol challenge caused a more marked and prolonged increase in RTFO. Thus aerosol delivery of a low dose of a cardiac glycoside or a near-isosmotic, ion-free, impermeant osmolyte solution may be therapeutically useful by increasing the clearance of secretions from the tracheobronchial airways.<\/jats:p>","DOI":"10.1152\/jappl.2001.90.3.821","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T03:38:18Z","timestamp":1514000298000},"page":"821-831","source":"Crossref","is-referenced-by-count":13,"title":["Ion transport and regulation of respiratory tract fluid output in dogs"],"prefix":"10.1152","volume":"90","author":[{"given":"Ben T.","family":"Chen","sequence":"first","affiliation":[{"name":"Departments of Medicine and"},{"name":"Chemical Engineering, University of Illinois at Chicago, and"},{"name":"Department of Veterans Affairs, Veterans Affairs Chicago Health Care System, Chicago, Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donovan 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