{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:38:18Z","timestamp":1791398298857,"version":"4.3.3"},"reference-count":37,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:p> Phrenic nerve afferents (PNa) have been shown to activate neurons in the spinal cord, brain stem, and forebrain regions. The c-Fos technique has been widely used as a method to identify neuronal regions activated by afferent stimulation. This technique was used to identify central neural areas activated by PNa. The right phrenic nerve of urethane-anesthetized rats was stimulated in the thorax. The spinal cord and brain were sectioned and stained for c-Fos expression. Labeled neurons were found in the dorsal horn laminae I and II of the C<jats:sub>3<\/jats:sub>\u2013C<jats:sub>5<\/jats:sub> spinal cord ipsilateral to the site of PNa stimulation. c-Fos-labeled neurons were found bilaterally in the medial subnuclei of the nucleus of the solitary tract, rostral ventral respiratory group, and ventrolateral medullary reticular formation. c-Fos-labeled neurons were found bilaterally in the paraventricular and supraoptic hypothalamic nuclei, in the paraventricular thalamic nucleus, and in the central nucleus of the amygdala. The presence of c-Fos suggests that these neurons are involved in PNa information processing and a component of the central mechanisms regulating respiratory function. <\/jats:p>","DOI":"10.1152\/jappl.2001.90.4.1291","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T22:23:54Z","timestamp":1513981434000},"page":"1291-1298","source":"Crossref","is-referenced-by-count":20,"title":["c-Fos expression in the central nervous system elicited by phrenic nerve stimulation"],"prefix":"10.1152","volume":"90","author":[{"given":"O. E.","family":"Malakhova","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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