{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:37:20Z","timestamp":1777635440334,"version":"3.51.4"},"reference-count":39,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:p>Obesity is often associated with a reduced ventilatory response and a decreased maximal exercise capacity. GABA is a major inhibitory neurotransmitter in the mammalian central nervous system. Altered GABAergic mechanisms have been detected in obese Zucker rats and implicated in their hyperphagic response. Whether altered GABAergic mechanisms also contribute to regulate ventilation and influence exercise capacity in obese Zucker rats is unknown and formed the basis of the present study. Eight lean [317 \u00b1 18 (SD) g] and eight obese (450 \u00b1 27 g) Zucker rats were studied at 12 wk of age. Ventilation at rest and ventilation during hypoxic (10% O<jats:sub>2<\/jats:sub>) and hypercapnic (4% CO<jats:sub>2<\/jats:sub>) challenges were measured by the barometric method. Peak O<jats:sub>2<\/jats:sub>consumption (V\u02d9o<jats:sub>2\u2009peak<\/jats:sub>) in response to a progressive treadmill test to exhaustion was measured in a metabolic treadmill. Ventilation and V\u02d9o<jats:sub>2\u2009peak<\/jats:sub>were assessed after administration of equal volumes of DMSO (vehicle) and the GABA<jats:sub>A<\/jats:sub>receptor antagonist bicuculline (1 mg\/kg). In lean animals, bicuculline administration had no effect on ventilation andV\u02d9o<jats:sub>2\u2009peak<\/jats:sub>. In obese rats, bicuculline administration significantly ( P &lt; 0.05) increased resting ventilation (465 \u00b1 53 and 542 \u00b1 72 ml \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>for control and bicuculline, respectively), ventilation during exposure to hypoxia (899 \u00b1 148 and 1,038 \u00b1 83 ml \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>for control and bicuculline, respectively), andV\u02d9o<jats:sub>2\u2009peak<\/jats:sub>(62 \u00b1 3.7 and 67 \u00b1 3.5 ml \u00b7 kg<jats:sup>\u22120.75<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>for control and bicuculline, respectively). However, in obese Zucker rats, ventilation in response to hypercapnia did not change after bicuculline administration (608 \u00b1 96 vs. 580 \u00b1 69 ml \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>). Our findings indicate that endogenous GABA depresses ventilation and limits exercise performance in obese Zucker rats.<\/jats:p>","DOI":"10.1152\/jappl.2001.90.5.1707","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T03:01:06Z","timestamp":1513998066000},"page":"1707-1713","source":"Crossref","is-referenced-by-count":18,"title":["GABAergic modulation of ventilation and peak oxygen consumption in obese Zucker rats"],"prefix":"10.1152","volume":"90","author":[{"given":"Shin-Da","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Exercise, and Nutrition Sciences, State University of New York at Buffalo, Buffalo, New York 14214-3079"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Exercise, and Nutrition Sciences, State University of New York at Buffalo, Buffalo, New York 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