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Two methods are compared: For case A, the liquid drains by gravity into the upper airways followed by inspiration; for case B, the liquid initially forms a plug in the trachea, followed by inspiration. Experiments are continuously recorded using a microfocal X-ray source and an image-intensifier, charge-coupled device image train. Video images recorded at 30 images\/s are digitized and analyzed. Transport dynamics during the first few breaths are quantified statistically and follow trends for liquid plug propagation theory. A plug of liquid driven by forced air can reach alveolar regions within the first few breaths. Homogeneity of distribution measured at end inspiration for several breaths demonstrates that case B is twice as homogeneous as case A. The formation of a liquid plug in the trachea, before inspiration, is important in creating a more uniform liquid distribution throughout the lungs.<\/jats:p>","DOI":"10.1152\/jappl.2001.90.5.1955","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T22:01:06Z","timestamp":1513980066000},"page":"1955-1967","source":"Crossref","is-referenced-by-count":45,"title":["A rat lung model of instilled liquid transport in the pulmonary airways"],"prefix":"10.1152","volume":"90","author":[{"given":"K. J.","family":"Cassidy","sequence":"first","affiliation":[{"name":"Departments of Mechanical Engineering and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Bull","sequence":"additional","affiliation":[{"name":"Departments of Mechanical Engineering and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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