{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:22:47Z","timestamp":1760955767119},"reference-count":30,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:p>The combined effects of endurance run training and renal hypertension on cytosolic Ca<jats:sup>2+<\/jats:sup>concentration ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub>) dynamics and Na<jats:sup>+<\/jats:sup>-dependent Ca<jats:sup>2+<\/jats:sup>regulation in rat left ventricular cardiomyocytes were examined. Male Fischer 344 rats underwent stenosis of the left renal artery [hypertensive (Ht), n = 18] or a sham operation [normotensive (Nt), n = 20]. One-half of the rats from each group were treadmill trained for &gt;16 wk. Cardiomyocyte fura 2 fluorescence ratio transients were recorded for 7 min during electrical pacing at 0.5 Hz, 2 mM extracellular Ca<jats:sup>2+<\/jats:sup>concentration, and 29\u00b0C. The rate of [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub>decline was not changed by run training in the Nt group but was reduced in the Ht group. At 7 min, cardiomyocytes were exposed to 10 mM caffeine in the absence of Na<jats:sup>+<\/jats:sup>and Ca<jats:sup>2+<\/jats:sup>, which triggered sarcoplasmic reticular Ca<jats:sup>2+<\/jats:sup>release and suppressed Ca<jats:sup>2+<\/jats:sup>efflux via Na<jats:sup>+<\/jats:sup>\/Ca<jats:sup>2+<\/jats:sup>exchanger. External Na<jats:sup>+<\/jats:sup>was then added, and Na<jats:sup>+<\/jats:sup>-dependent Ca<jats:sup>2+<\/jats:sup>efflux rate was recorded. Treadmill training significantly enhanced Na<jats:sup>+<\/jats:sup>-dependent Ca<jats:sup>2+<\/jats:sup>efflux rate under these conditions in the Nt group but not in the Ht group. These data provide evidence that renal hypertension prevents the normal run training-induced modifications in diastolic [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub>regulation mechanisms, including Na<jats:sup>+<\/jats:sup>\/Ca<jats:sup>2+<\/jats:sup>exchanger.<\/jats:p>","DOI":"10.1152\/jappl.2001.90.6.2063","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T21:38:33Z","timestamp":1513978713000},"page":"2063-2069","source":"Crossref","is-referenced-by-count":13,"title":["Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca<sup>2+<\/sup>regulation in male rats"],"prefix":"10.1152","volume":"90","author":[{"given":"Bradley M.","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, Colorado 80309"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua 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