{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:31:05Z","timestamp":1790793065188,"version":"4.1.0"},"reference-count":23,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:p>The purpose of this study was to determine whether aspirin (A) ingestion combined with prolonged exercise increases gastrointestinal permeability and whether consumption of a carbohydrate-containing (CHO) or a CHO + glutamine-containing (CHO+G) beverage would reduce this effect. Seventeen subjects completed six experiments. They ingested A (1,300 mg) or placebo (P) pills the evening before and before running 60 min at 70% maximal oxygen uptake. Also, before running they ingested a solution containing 5 g lactulose (L), 5 g sucrose (S), and 2 g rhamnose (R). During each trial, either a 6% CHO beverage, a 6% CHO+G (0.6%; 41 mM) beverage, or a water placebo (WP) was consumed. For 4 h after a run, all urine was collected to measure urinary excretion of L, R, and S. S excretion (percentage of dose ingested; measure of gastroduodenal permeability) was significantly greater ( P &lt; 0.05) during the A trial while the subjects drank the WP compared with all other trials. Administration of A also significantly increased L\/R (measure of intestinal permeability) for the CHO and WP trials compared with all P trials. Ingestion the CHO or CHO+G beverages significantly reduced S excretion and L excretion when A was administered, but it did not reduce L\/R. These results indicate that gastroduodenal and intestinal permeability increase after A ingestion during prolonged running and that ingestion of a CHO beverage attenuates the gastroduodenal effect but not the intestinal effect. Furthermore, addition of G to the CHO beverage provided no additional benefit in reducing gastroduodenal or intestinal permeability.<\/jats:p>","DOI":"10.1152\/jappl.2001.90.6.2075","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T21:38:33Z","timestamp":1513978713000},"page":"2075-2080","source":"Crossref","is-referenced-by-count":84,"title":["Gastrointestinal permeability during exercise: effects of aspirin and energy-containing beverages"],"prefix":"10.1152","volume":"90","author":[{"given":"G. 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