{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:48:33Z","timestamp":1772192913765,"version":"3.50.1"},"reference-count":30,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:p>To determine whether the inhibition of nitric oxide (NO) synthesis attenuates thermally induced obstruction, we had 10 asthmatic volunteers perform isocapnic hyperventilation with frigid air after inhaling 1 mg of N<jats:sup>G<\/jats:sup>-monomethyl-l-arginine (l-NMMA) or isotonic saline in a blinded fashion. The challenges were identical in all respects, and there were no differences in baseline lung function [1-s forced expiratory volume (FEV<jats:sub>1<\/jats:sub>); saline 2.8 \u00b1 0.3 liters, l-NMMA 2.9 \u00b1 0.3 liters; P = 0.41] or prechallenge fractional concentration of nitric oxide in the exhaled air (FeNO) [saline 23 \u00b1 6 parts\/billion (ppb),l-NMMA 18 \u00b1 4 ppb; P = 0.51]. Neither treatment had any impact on the FEV<jats:sub>1<\/jats:sub>, pulse, or blood pressure. After l-NMMA, FeNO fell significantly ( P &lt; 0.0001), the stimulus-response curves shifted to the right, and the minute ventilation required to reduce the FEV<jats:sub>1<\/jats:sub>20% rose 53.5% over control ( P = 0.02). The results of this study demonstrate that NO generated from the airways of asthmatic individuals may play an important role in the pathogenesis of thermally induced asthma.<\/jats:p>","DOI":"10.1152\/jappl.2001.91.2.703","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T21:19:41Z","timestamp":1513977581000},"page":"703-708","source":"Crossref","is-referenced-by-count":11,"title":["Inhibition of nitric oxide synthesis attenuates thermally induced asthma"],"prefix":"10.1152","volume":"91","author":[{"given":"C.","family":"Kotaru","sequence":"first","affiliation":[{"name":"Airway Disease Center, Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, and Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Skowronski","sequence":"additional","affiliation":[{"name":"Airway Disease Center, Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, and Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Coreno","sequence":"additional","affiliation":[{"name":"Airway Disease Center, Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, and Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"E. 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