{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:17:37Z","timestamp":1791119857134,"version":"4.1.0"},"reference-count":44,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:p>Seventeen fit women ran to exhaustion (14 \u00b1 4 min) at a constant speed and grade, reaching 95 \u00b1 3% of maximal O<jats:sub>2<\/jats:sub>consumption. Pre- and postexercise lung function, including airway resistance [total respiratory resistance (Rrs)] across a range of oscillation frequencies, was measured, and, on a separate day, airway reactivity was assessed via methacholine challenge. Arterial O<jats:sub>2<\/jats:sub>saturation decreased from 97.6 \u00b1 0.5% at rest to 95.1 \u00b1 1.9% at 1 min and to 92.5 \u00b1 2.6% at exhaustion. Alveolar-arterial O<jats:sub>2<\/jats:sub>difference (A-aDo<jats:sub>2<\/jats:sub>) widened to 27 \u00b1 7 Torr after 1 min and was maintained at this level until exhaustion. Arterial Po<jats:sub>2<\/jats:sub>(Pa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>) fell to 80 \u00b1 8 Torr at 1 min and then increased to 86 \u00b1 9 Torr at exhaustion. This increase in Pa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>over the exercise duration occurred due to a hyperventilation-induced increase in alveolar Po<jats:sub>2<\/jats:sub>in the presence of a constant A-aDo<jats:sub>2<\/jats:sub>. Arterial O<jats:sub>2<\/jats:sub>saturation fell with time because of increasing temperature (+2.6 \u00b1 0.5\u00b0C) and progressive metabolic acidosis (arterial pH: 7.39 \u00b1 0.04 at 1 min to 7.26 \u00b1 0.07 at exhaustion). Plasma histamine increased throughout exercise but was inversely correlated with the fall in Pa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>at end exercise. Neither pre- nor postexercise Rrs, frequency dependence of Rrs, nor diffusing capacity for CO correlated with the exercise A-aDo<jats:sub>2<\/jats:sub>or Pa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>. Although several subjects had a positive or borderline hyperresponsiveness to methacholine, this reactivity did not correlate with exercise-induced changes in Rrs or exercise-induced arterial hypoxemia. In conclusion, regardless of the degree of exercise-induced arterial hypoxemia at the onset of high-intensity exercise, prolonging exercise to exhaustion had no further deleterious effects on A-aDo<jats:sub>2<\/jats:sub>, and the degree of gas exchange impairment was not related to individual differences in small or large airway function or reactivity.<\/jats:p>","DOI":"10.1152\/jappl.2001.91.2.847","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T21:19:41Z","timestamp":1513977581000},"page":"847-858","source":"Crossref","is-referenced-by-count":48,"title":["Effects of exhaustive endurance exercise on pulmonary gas exchange and airway function in women"],"prefix":"10.1152","volume":"91","author":[{"given":"Thomas J.","family":"Wetter","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin 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