{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:27:36Z","timestamp":1759962456409},"reference-count":17,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"<jats:p>To evaluate the transport properties of the alveolar epithelium, we instilled hetastarch (Het; 6%, 10 ml, 1 \u2212 1 \u00d7 10<jats:sup>4<\/jats:sup>kDa) into the trachea of isolated rat lungs and then measured the molecular distribution of Het that entered the lung perfusate from the air space over 6 h. Het transport was driven by either diffusion or an oncotic gradient. Perfusate Het had a unique, bimodal molecular weight distribution, consisting of a narrow low-molecular-weight peak at 10\u201315 kDa (range, 5\u201346 kDa) and a broad high-molecular-weight band (range 46\u20132,000 kDa; highest at 288 kDa). We modeled the low-molecular-weight transport as (passive) restricted diffusion or osmotic flow through a small-pore system and the high-molecular-weight transport as passive transport through a large-pore system. The equivalent small-pore radius was 5.0 nm, with a distribution of 150 pores per alveolus. The equivalent large-pore radius was 17.0 nm, with a distribution of one pore per seven alveoli. The small-pore fluid conductivity (2 \u00d7 10<jats:sup>\u22125<\/jats:sup>ml \u00b7 h<jats:sup>\u22121<\/jats:sup>\u00b7 cm<jats:sup>\u22122<\/jats:sup>\u00b7 mmHg<jats:sup>\u22121<\/jats:sup>) was 10-fold larger than that of the large-pore conductivity.<\/jats:p>","DOI":"10.1152\/jappl.2001.91.4.1730","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T22:03:02Z","timestamp":1513980182000},"page":"1730-1740","source":"Crossref","is-referenced-by-count":13,"title":["Transport properties of alveolar epithelium measured by molecular hetastarch absorption in isolated rat lungs"],"prefix":"10.1152","volume":"91","author":[{"given":"Robert L.","family":"Conhaim","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Wisconsin-Madison, The William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53792-7375; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kal E.","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wisconsin-Madison, The William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53792-7375; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Lai-Fook","sequence":"additional","affiliation":[{"name":"Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Harms","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wisconsin-Madison, The William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53792-7375; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(74)85962-X"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.4.1277"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.5.1887"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.3.1134"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.43.1.72"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.5.1431"},{"key":"B7","first-page":"657","volume":"20","author":"Ghitescu L","year":"1988","journal-title":"J Submicrosc Cytol Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1995.269.4.L453"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1994.266.5.L544"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.4.9105071"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.4.1261"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1021\/js960352x"},{"key":"B14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0272-5231(21)00378-6","volume":"6","author":"Matthay MA.","year":"1985","journal-title":"Clin Chest Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.3.928"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(75)85884-X"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/197054a0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1039\/f19827803357"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.2001.91.4.1730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T03:09:33Z","timestamp":1660187373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.2001.91.4.1730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,1]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,10,1]]}},"alternative-id":["10.1152\/jappl.2001.91.4.1730"],"URL":"https:\/\/doi.org\/10.1152\/jappl.2001.91.4.1730","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,1]]}}}