{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:34:47Z","timestamp":1758814487858},"reference-count":40,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:p> Nasal nitric oxide (NO) exchange dynamics are poorly understood but potentially are of importance, inasmuch as they may provide insight into the NO-related physiology of the bronchial tree. In healthy human volunteers, NO output was assessed by isolating the nasal cavity through elevation of the soft palate and application of tight-fitting nasal olives. Mean NO output was 334 nl\/min and was a positive function of gas flow. With the use of a mathematical model and the introduction of nonzero concentrations of NO, the diffusing capacity for NO in the nose (D<jats:sub>NO<\/jats:sub>) and the mucosal NO concentration (C<jats:sub>w<\/jats:sub>) were determined. D<jats:sub>NO<\/jats:sub> ranged from 0.52 to 2.98 \u00d7 10<jats:sup>\u22123<\/jats:sup>nl \u00b7 s<jats:sup>\u22121<\/jats:sup> \u00b7 ppb<jats:sup>\u22121<\/jats:sup> and C<jats:sub>w<\/jats:sub> from 1,236 to 8,947 ppb. C<jats:sub>w<\/jats:sub> declined with increasing gas flow, while D<jats:sub>NO<\/jats:sub> was constant. NO output declined with luminal hypoxia, particularly at oxygen tensions &lt;10%. Measurement of nasal D<jats:sub>NO<\/jats:sub> and C<jats:sub>w<\/jats:sub> is easy using this method, and the range of intersubject values of C<jats:sub>w<\/jats:sub>raises the possibility of interindividual differences in NO-dependent nasal physiology. <\/jats:p>","DOI":"10.1152\/jappl.2001.91.5.1924","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T16:42:38Z","timestamp":1513960958000},"page":"1924-1930","source":"Crossref","is-referenced-by-count":12,"title":["Exchange dynamics of nitric oxide in the human nose"],"prefix":"10.1152","volume":"91","author":[{"given":"Daniel C.","family":"Chambers","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Birmingham Heartlands Hospital, Birmingham B9 5SS; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic A.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"St. Hugh's College, University of Oxford, Oxford OX2 6LE, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon G.","family":"Ayres","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Birmingham Heartlands Hospital, Birmingham B9 5SS; 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