{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:38:38Z","timestamp":1791027518721,"version":"4.1.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:p>The purpose of this study was to examine the effect of therapeutic levels of clenbuterol, with and without exercise training, on body composition. Twenty-three unfit Standardbred mares were divided into four experimental groups: clenbuterol (2.4 \u03bcg\/kg body wt twice daily) plus exercise (ClenEx; 20 min at 50% maximal oxygen consumption 3days\/wk; n = 6), clenbuterol only (Clen; n = 6), exercise only (Ex; n = 5), and control (Con; n = 6). Rump fat thickness was measured at 2-wk intervals by using B-mode ultrasound, and percent body fat (%fat) was calculated by using previously published methods. For Ex, body fat decreased ( P &lt; 0.05) at week 4 (\u22129.3%), %fat at week 6 (\u22126.9%), and fat-free mass (FFM) increased ( P &lt; 0.05) at week 8 (+3.2%). On the other hand, Clen had significant changes in %fat (\u221215.4%), fat mass (\u221214.7%), and FFM (+4.3%) at week 2. ClenEx had significant decreases in %fat (\u221217.6%) and fat mass (\u221219.5%) at week 2, which was similar to Clen; however, this group had a different FFM response, which significantly increased (+4.4%) at week 6. Con showed no changes ( P &gt; 0.05) in any variable at any time. These results suggest that exercise training and clenbuterol have additive effects with respect to %fat and fat mass but antagonistic effects in terms of FFM. Furthermore, chronic clenbuterol administration causes significant repartitioning in the horse, even when administered in therapeutic doses.<\/jats:p>","DOI":"10.1152\/jappl.2001.91.5.2064","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T21:42:38Z","timestamp":1513978958000},"page":"2064-2070","source":"Crossref","is-referenced-by-count":54,"title":["Chronic administration of therapeutic levels of clenbuterol acts as a repartitioning agent"],"prefix":"10.1152","volume":"91","author":[{"given":"Charles F.","family":"Kearns","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth H.","family":"McKeever","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901; 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