{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:11:42Z","timestamp":1790802702138,"version":"4.1.0"},"reference-count":34,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p> Phrenic nerve stimulation (PNS) can assess airflow dynamics of the upper airway (UA) during wakefulness in man. Using PNS, we aimed to assess the impact of neck flexion and mouth opening in promoting UA unstability. Measurements were made during nasal breathing in seven healthy subjects (ages = 23\u201339 yr; one woman). Surface diaphragm electromyogram, esophageal pressure referenced to mask pressure, and flow were recorded during diaphragm twitches with neck in neutral position and mouth closed and then with neck flexion and\/or mouth opening. Twitches always exhibited a flow-limited pattern. Flow-limiting driving pressure (Pd) and peak Pd were increased by neck flexion ( P &lt; 0.01) without significant change in the corresponding flows. UA resistances at these flow values were higher with the neck flexed ( P &lt; 0.05). Mouth opening alone did not exert any significant influence. We conclude that the position of the neck has a discernible impact on the flow behavior through the nonphasically active UA faced with a negative Pd. <\/jats:p>","DOI":"10.1152\/jappl.2002.92.1.84","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T23:25:08Z","timestamp":1513985108000},"page":"84-92","source":"Crossref","is-referenced-by-count":26,"title":["Effects of neck flexion and mouth opening on  inspiratory flow dynamics in awake humans"],"prefix":"10.1152","volume":"92","author":[{"given":"Eric","family":"Verin","sequence":"first","affiliation":[{"name":"Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie,"},{"name":"Unit\u00e9 Propre de Recherche de l'Enseignement Sup\u00e9rieur EA 2397, Universit\u00e9 Paris VI Pierre et Marie Curie, 75005 Paris;"},{"name":"Service de Physiologie, Centre Hospitalier Universitaire de Rouen, 76031 Rouen, France; and"},{"name":"Centre de Recherche, H\u00f4pital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Universit\u00e9 Laval, Quebec, Canada G1V 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"S\u00e9ri\u00e8s","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Propre de Recherche de l'Enseignement Sup\u00e9rieur EA 2397, Universit\u00e9 Paris VI Pierre et Marie Curie, 75005 Paris;"},{"name":"Centre de Recherche, H\u00f4pital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Universit\u00e9 Laval, Quebec, Canada G1V 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chryst\u00e8le","family":"Locher","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie,"},{"name":"Unit\u00e9 Propre de Recherche de l'Enseignement Sup\u00e9rieur EA 2397, Universit\u00e9 Paris VI Pierre et Marie Curie, 75005 Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Straus","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie,"},{"name":"Service Central d'Explorations Fonctionnelles Respiratoires, Assistance Publique-H\u00f4pitaux de Paris, Groupe Hospitalier Piti\u00e9 Salpetri\u00e8re, 75651 Paris;"},{"name":"Unit\u00e9 Propre de Recherche de l'Enseignement Sup\u00e9rieur EA 2397, Universit\u00e9 Paris VI Pierre et Marie Curie, 75005 Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Zelter","sequence":"additional","affiliation":[{"name":"Service Central d'Explorations Fonctionnelles Respiratoires, Assistance Publique-H\u00f4pitaux de Paris, Groupe Hospitalier Piti\u00e9 Salpetri\u00e8re, 75651 Paris;"},{"name":"Unit\u00e9 Propre de Recherche de l'Enseignement Sup\u00e9rieur EA 2397, Universit\u00e9 Paris VI Pierre et Marie Curie, 75005 Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Derenne","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie,"},{"name":"Unit\u00e9 Propre de Recherche de l'Enseignement Sup\u00e9rieur EA 2397, Universit\u00e9 Paris VI Pierre et Marie Curie, 75005 Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie,"},{"name":"Unit\u00e9 Propre de Recherche de l'Enseignement Sup\u00e9rieur EA 2397, Universit\u00e9 Paris VI Pierre et Marie Curie, 75005 Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.5.1158"},{"key":"B2","first-page":"788","volume":"126","author":"Baydur A","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.46.4.772"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.49.5.801"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.1.54"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.6.1300"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.6.2267"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.4.1403"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.2.443"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199904000-00042"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30984-1"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.2.584"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.3.1285"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542125"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.44.6.931"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/thx.45.10.722"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.6.2171"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1959.14.5.760"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.3_Pt_1.494"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.suppl_10.184"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.3.527"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.4.1626"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.2.535"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.9812036"},{"key":"B25","first-page":"182","volume":"163","author":"S\u00e9ri\u00e8s F","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9906135"},{"key":"B27","first-page":"609","volume":"5","author":"Similowski T","year":"1988","journal-title":"Rev Mal Respir"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.4.1190"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.2.328"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.2.789"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.49.4.638"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.3.1076"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.5.2084"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.48.3.500"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.2002.92.1.84","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T19:22:46Z","timestamp":1567970566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.2002.92.1.84"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1,1]]}},"alternative-id":["10.1152\/jappl.2002.92.1.84"],"URL":"https:\/\/doi.org\/10.1152\/jappl.2002.92.1.84","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,1]]}}}