{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:27:59Z","timestamp":1774510079901,"version":"3.50.1"},"reference-count":48,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health (OER)","doi-asserted-by":"publisher","award":["R01HL128388"],"award-info":[{"award-number":["R01HL128388"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health (OER)","doi-asserted-by":"publisher","award":["R01HL113270"],"award-info":[{"award-number":["R01HL113270"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","award":["18POST34060020"],"award-info":[{"award-number":["18POST34060020"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006094","name":"University of Delaware (UD)","doi-asserted-by":"publisher","award":["Doctoral Fellowship"],"award-info":[{"award-number":["Doctoral Fellowship"]}],"id":[{"id":"10.13039\/100006094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences (NIGMS)","doi-asserted-by":"publisher","award":["5 P30 GM113125"],"award-info":[{"award-number":["5 P30 GM113125"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:p> Excess dietary salt intake excites central sympathetic networks, which may be related to plasma hypernatremia. Plasma hypernatremia also occurs following water deprivation (WD). The purpose of this study was to test the hypothesis that WD induces hypernatremia and consequently augments sympathetic and pressor responses to sympathoexcitatory stimuli in rats and humans. Sympathetic nerve activity (SNA) and arterial blood pressure (ABP) responses to sciatic afferent nerve stimulation (2\u201320 Hz) and chemical stimulation of the rostral ventrolateral medulla (RVLM) were assessed in rats after 48 h of WD and compared with normally hydrated control rats (CON). In a parallel randomized-crossover human experiment ( n = 13 healthy young adults), sympathetic (microneurography) and pressor (photoplethysmography) responses to static exercise were compared between 16-h WD and CON conditions. In rats, plasma [Na<jats:sup>+<\/jats:sup>] was significantly higher in WD versus CON [136\u2009\u00b1\u20092 vs. 144\u2009\u00b1\u20092 (SD) mM, P &lt; 0.01], but sciatic afferent nerve stimulation produced similar increases in renal SNA [5 Hz, 174\u2009\u00b1\u200934 vs. 169\u2009\u00b1\u200949% (SD), n = 6\u20138] and mean ABP [5 Hz, 21\u2009\u00b1\u20096 vs. 18\u2009\u00b1\u20097 (SD mmHg, n = 6\u20138]. RVLM injection of l-glutamate also produced similar increases in SNA and ABP in WD versus CON rats. In humans, WD increased serum [Na<jats:sup>+<\/jats:sup>] [140.6\u2009\u00b1\u20092.1 vs. 142.1\u2009\u00b1\u20091.9 mM (SD), P = 0.02] but did not augment sympathetic [muscle SNA: change from baseline (\u0394) 6\u2009\u00b1\u20097 vs. 5\u2009\u00b1\u20097 (SD) bursts\/min, P = 0.83] or mean ABP [\u0394 12\u2009\u00b1\u20095 vs. 11\u2009\u00b1\u20098 (SD) mmHg, P = 0.73; WD vs. CON for all results] responses during the final minute of exercise. These findings suggest that despite eliciting relative hypernatremia, WD does not augment sympathetic or pressor responses to sciatic afferent stimulation in rats or to static exercise in humans. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Excess dietary salt intake excites central sympathetic networks, which may be related to plasma hypernatremia. Plasma hypernatremia also occurs following water deprivation (WD). We sought to determine whether plasma hypernatremia\/hyperosmolality induced by WD augments sympathetic and pressor responses to sympathoexcitatory stimuli. Our findings suggest that WD does not augment sympathetic or pressor responses to sciatic afferent nerve stimulation in rats or to static exercise in humans. <\/jats:p>","DOI":"10.1152\/japplphysiol.00005.2019","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T14:39:59Z","timestamp":1557412799000},"page":"235-245","source":"Crossref","is-referenced-by-count":17,"title":["Water deprivation does not augment sympathetic or pressor responses to sciatic afferent nerve stimulation in rats or to static exercise in humans"],"prefix":"10.1152","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-0643","authenticated-orcid":false,"given":"Joseph C.","family":"Watso","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Applied Physiology, University of Delaware, Newark, 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