{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:09:36Z","timestamp":1790460576564,"version":"4.1.0"},"reference-count":48,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2016,5,15]]},"abstract":"<jats:p>We determined the effects of chronic exposure to intermittent hypoxia (CIH) on chemoreflex control of ventilation in conscious animals. Adult male Sprague-Dawley rats were exposed to CIH [nadir oxygen saturation (SpO<jats:sub>2<\/jats:sub>), 75%; 15 events\/h; 10 h\/day] or normoxia (NORM) for 21 days. We assessed the following responses to acute, graded hypoxia before and after exposures: ventilation (V\u0307e, via barometric plethysmography), V\u0307o<jats:sub>2<\/jats:sub>and V\u0307co<jats:sub>2<\/jats:sub>(analysis of expired air), heart rate (HR), and SpO<jats:sub>2<\/jats:sub>(pulse oximetry via neck collar). We quantified hypoxia-induced chemoreceptor sensitivity by calculating the stimulus-response relationship between SpO<jats:sub>2<\/jats:sub>and the ventilatory equivalent for V\u0307co<jats:sub>2<\/jats:sub>(linear regression). An additional aim was to determine whether CIH causes proliferation of carotid body glomus cells (using bromodeoxyuridine). CIH exposure increased the slope of the V\u0307e\/V\u0307co<jats:sub>2<\/jats:sub>\/SpO<jats:sub>2<\/jats:sub>relationship and caused hyperventilation in normoxia. Bromodeoxyuridine staining was comparable in CIH and NORM. Thus our CIH paradigm augmented hypoxic chemosensitivity without causing glomus cell proliferation.<\/jats:p>","DOI":"10.1152\/japplphysiol.00015.2016","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T04:09:56Z","timestamp":1456459796000},"page":"1186-1195","source":"Crossref","is-referenced-by-count":20,"title":["Chronic intermittent hypoxia alters ventilatory and metabolic responses to acute hypoxia in rats"],"prefix":"10.1152","volume":"120","author":[{"given":"Barbara J.","family":"Morgan","sequence":"first","affiliation":[{"name":"John Rankin Laboratory of Pulmonary Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin;"},{"name":"Department of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Adrian","sequence":"additional","affiliation":[{"name":"John Rankin 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