{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:18:23Z","timestamp":1776485903841,"version":"3.51.2"},"reference-count":34,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p> The effects of intravenous norepinephrine (NE, group 1) and vasopressin (AVP, group 2) infusions on systemic, splanchnic, and renal circulations were studied in anesthetized dogs under basal conditions and during endotoxic shock. Under basal conditions, AVP infusion induced a 12 \u00b1 7% drop in left ventricular stroke work, a 45 \u00b1 5% fall in portal venous blood flow, and a 31 \u00b1 13% decrease in intestinal mucosal blood flow ( P &lt; 0.05). AVP also decreased splanchnic oxygen delivery (Do<jats:sub>2<\/jats:sub>) and increased splanchnic and renal oxygen extraction significantly during basal conditions. Except for more pronounced brady-cardia among animals in group 2, the systemic and splanchnic changes were comparable between study groups during endotoxic shock. AVP infusion restored renal blood flow and Do<jats:sub>2<\/jats:sub> in endotoxic shock compared with animals resuscitated with NE, which had persistently low renal blood flow and Do<jats:sub>2<\/jats:sub>. Our data demonstrate that, in contrast to NE, administration of AVP effectively restores renal blood flow and Do<jats:sub>2<\/jats:sub> with comparable systemic and splanchnic hemodynamic and metabolic effects in endotoxin-induced circulatory shock. <\/jats:p>","DOI":"10.1152\/japplphysiol.00017.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:46:02Z","timestamp":1425397562000},"page":"803-809","source":"Crossref","is-referenced-by-count":61,"title":["Vasopressin vs. norepinephrine in endotoxic shock: systemic, renal, and  splanchnic hemodynamic and oxygen transport effects"],"prefix":"10.1152","volume":"95","author":[{"given":"Jorge A.","family":"Guzman","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Wayne State  University School of Medicine, Detroit, Michigan 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariosto E.","family":"Rosado","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Wayne State  University School of Medicine, Detroit, Michigan 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Kruse","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Wayne State  University School of Medicine, Detroit, Michigan 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9802055"},{"key":"REF2","unstructured":"Chernow B and  Roth BL. Pharmacologic manipulation of the peripheral vasculature in  shock: clinical and experimental approaches. Circ  Shock 18:  141-155, 1986."},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.34.4.505"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1989.256.2.F274"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.4.1241"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91452-Z"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199903000-00015"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1994.267.2.F249"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.3.989"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.5.1122"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115820"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra002709"},{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<343::AID-PATH522>3.0.CO;2-M"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1982.243.5.H663"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.265.3.R524"},{"key":"REF16","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199910000-00014"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.3.H1087"},{"key":"REF18","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198707000-00012"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01197-2"},{"key":"REF20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.1.387"},{"key":"REF21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1973.tb08154.x"},{"key":"REF22","unstructured":"Parrillo JE,  Parker MM, Natanson C, Suffredini AF, Danner RL, Cunnion RE, and Ognibene  FP. Septic shock in humans: advances in the understanding of pathogenesis,  cardio-vascular dysfunction, and therapy. Ann Intern  Med 13: 227-242,  1990."},{"key":"REF23","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200203000-00011"},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1960.40.2.187"},{"key":"REF25","doi-asserted-by":"publisher","DOI":"10.1159\/000159082"},{"key":"REF26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1994.266.4.G633"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.249.6.H1086"},{"key":"REF28","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200206000-00032"},{"key":"REF29","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200103000-00004"},{"key":"REF30","unstructured":"Vanhoutte PM,  Katusic ZS, and Shepherd JT. Vasopressin induces endothelium-dependent  relaxations of cerebral and coronary, but not of systemic arteries.  J Hypertens 2, Suppl:  S421-S422, 1984."},{"key":"REF31","doi-asserted-by":"publisher","DOI":"10.1007\/PL00003799"},{"key":"REF32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.263.2.H491"},{"key":"REF33","doi-asserted-by":"crossref","unstructured":"Wheeler AP and  Bernard GR. Treating patients with severe sepsis. N Engl J  Med 340: 204-214,  1999.","DOI":"10.1056\/NEJM199901213400307"},{"key":"REF34","unstructured":"Wilson MF,  Brackett DJ, Hinshaw LB, Tompkins P, Archer LT, and Benjamin BA.  Vasopressin release during sepsis and septic shock in baboons and dogs.  Surg Gynecol Obstet 153:  869-872, 1981."}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00017.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:38:54Z","timestamp":1567960734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00017.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1152\/japplphysiol.00017.2003"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00017.2003","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}