{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:28:18Z","timestamp":1791077298544,"version":"4.1.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p> An increase in the production of reactive oxygen species occurs with muscle disuse, ischemic cardiomyopathy, and conditions that arise with senescence. The resulting oxidative stress is associated with apoptosis-related myopathies. Recent research has suggested that chronic exercise is protective against mitochondrially mediated programmed cell death. To further investigate this, we compared soleus (Sol) and cardiac muscles of voluntary wheel-trained (T; 10 wk) and untrained (C) animals. Training produced a 52% increase in muscle cytochrome c oxidase (COX) activity. Sol and left ventricle (LV) strips were isolated and incubated in vitro with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> for 4 h. Strips were then fractionated into cytosolic and mitochondrial fractions. Whole muscle apoptosis-inducing factor (AIF) and Bax\/Bcl-2 levels were reduced in both the Sol and LV from T animals. H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> treatment induced increases in JNK phosphorylation, cofilin-2 localization to the mitochondria, as well as cytosolic AIF in both Sol and LV of T and C animals, respectively. Mitochondrial Bax and cytosolic cytochrome c were augmented under oxidative stress in the LV only. The H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-induced increases in P-JNK, mitochondrial Bax, and cytosolic AIF were ablated in the LV of T animals. These data suggest that short-term oxidative stress can induce apoptotic signaling in striated muscles in vitro. In addition, training can attenuate oxidative stress-induced apoptotic signaling in a tissue-specific manner, with an effect that is most prominent in cardiac muscle. <\/jats:p>","DOI":"10.1152\/japplphysiol.00020.2011","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T23:42:19Z","timestamp":1302219739000},"page":"1638-1645","source":"Crossref","is-referenced-by-count":33,"title":["Effects of endurance training on apoptotic susceptibility in striated muscle"],"prefix":"10.1152","volume":"110","author":[{"given":"Anna","family":"Vainshtein","sequence":"first","affiliation":[{"name":"School of Kinesiology and Health Science and the Muscle Health Research Center, York University, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Kazak","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Science and the Muscle Health Research Center, York University, Toronto, 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