{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:22:28Z","timestamp":1791091348268,"version":"4.1.0"},"reference-count":44,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p> We examined the effects of carotid body denervation on ventilatory responses to normoxia (21% O<jats:sub>2<\/jats:sub> in N<jats:sub>2<\/jats:sub> for 240 s), hypoxic hypoxia (10 and 15% O<jats:sub>2<\/jats:sub> in N<jats:sub>2<\/jats:sub> for 90 and 120 s, respectively), and hyperoxic hypercapnia (5% CO<jats:sub>2<\/jats:sub> in O<jats:sub>2<\/jats:sub> for 240 s) in the spontaneously breathing urethane-anesthetized mouse. Respiratory measurements were made with a whole body, single-chamber plethysmograph before and after cutting both carotid sinus nerves. Baseline measurements in air showed that carotid body denervation was accompanied by lower minute ventilation with a reduction in respiratory frequency. On the basis of measurements with an open-circuit system, no significant differences in O<jats:sub>2<\/jats:sub> consumption or CO<jats:sub>2<\/jats:sub> production before and after chemodenervation were found. During both levels of hypoxia, animals with intact sinus nerves had increased respiratory frequency, tidal volume, and minute ventilation; however, after chemodenervation, animals experienced a drop in respiratory frequency and ventilatory depression. Tidal volume responses during 15% hypoxia were similar before and after carotid body denervation; during 10% hypoxia in chemodenervated animals, there was a sudden increase in tidal volume with an increase in the rate of inspiration, suggesting that gasping occurred. During hyperoxic hypercapnia, ventilatory responses were lower with a smaller tidal volume after chemodenervation than before. We conclude that the carotid bodies are essential for maintaining ventilation during eupnea, hypoxia, and hypercapnia in the anesthetized mouse. <\/jats:p>","DOI":"10.1152\/japplphysiol.00025.2004","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T14:23:51Z","timestamp":1087309431000},"page":"1401-1407","source":"Crossref","is-referenced-by-count":36,"title":["Role of the carotid bodies in chemosensory ventilatory responses in the anesthetized mouse"],"prefix":"10.1152","volume":"97","author":[{"given":"Masahiko","family":"Izumizaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieczyslaw","family":"Pokorski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00706.2002"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(66)90006-5"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1982.sp002676"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.40.2.184"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.31.3.431"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(73)90062-5"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1967.sp008148"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(84)90096-3"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(02)00005-1"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5891-0_58"},{"key":"R11","unstructured":"Cunningham DJC, Lloyd BB, Miller JP, and Young JM. 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