{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:33:36Z","timestamp":1761896016560,"version":"3.41.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:p>We investigated the hemodynamic, renal, and hormonal responses to neutral endopeptidase (NEP) inhibition during a 6-h, double-blind, randomized, placebo-controlled study in seven chronic, stable heart transplant patients. Baseline characteristics were similar during both experiments, and no significant changes were observed after placebo. NEP inhibition increased circulating endothelin-1 (from 2.01 \u00b1 0.1 to 2.90 \u00b1 0.2 pmol\/l; P &lt; 0.01), atrial natriuretic peptide (ANP; from 21.5 \u00b1 2.7 to 29.6 \u00b1 3.7 pmol\/l; P &lt; 0.01), and the ANP second messenger cGMP. Noteworthy, systemic blood pressure did not increase. Renal plasma flow and glomerular filtration rate remained unmodified after NEP inhibition. Filtration fraction (33 \u00b1 13%), diuresis (196 \u00b1 62%), and natriuresis (315 \u00b1 105%) increased significantly in relation to ANP and cGMP. A strong inverse relationship was observed between excreted cGMP and sodium reabsorption ( r = \u22120.71, P &lt; 0.0001). Thus, despite significantly increasing endothelin-1, NEP inhibition did not adversely influence systemic or renal hemodynamics in transplant patients. ANP, possibly through a tubular action, enhances the natriuresis observed after NEP inhibition.<\/jats:p>","DOI":"10.1152\/japplphysiol.00027.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:41:23Z","timestamp":1425415283000},"page":"569-575","source":"Crossref","is-referenced-by-count":10,"title":["Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients"],"prefix":"10.1152","volume":"93","author":[{"given":"Fran\u00e7ois","family":"Piquard","sequence":"first","affiliation":[{"name":"Laboratoire des R\u00e9gulations Physiologiques et des Rythmes Biologiques chez l'Homme, Equipe d'Accueil 3072,"},{"name":"Service de Physiologie et d'Explorations Fonctionnelles, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruddy","family":"Richard","sequence":"additional","affiliation":[{"name":"Laboratoire des R\u00e9gulations Physiologiques et des Rythmes Biologiques chez l'Homme, 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