{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:36:49Z","timestamp":1776757009800,"version":"3.51.2"},"reference-count":36,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["81170019"],"award-info":[{"award-number":["81170019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["81270020"],"award-info":[{"award-number":["81270020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2015,9,15]]},"abstract":"<jats:p>In mammals, the neural control of airway smooth muscle is dominated by a subset of airway vagal preganglionic neurons in the ventrolateral medulla. These neurons are physiologically modulated by adrenergic\/noradrenergic projections, and weakened \u03b1<jats:sub>2<\/jats:sub>-adrenergic inhibition of them is indicated to participate in the pathogenesis and exacerbation of asthma. This study tests whether these neurons are modulated by \u03b1<jats:sub>1<\/jats:sub>-adrenoceptors, and if so, how. In anesthetized adult rats, microinjection of the \u03b1<jats:sub>1A<\/jats:sub>-adrenoceptor agonist A61603 (1 pmol) unilaterally into the medullary region containing these neurons caused a significant increase in airway resistance, which was prevented by intraperitoneal atropine (0.5 mg\/kg). In rhythmically firing medullary slices of newborn rats, A61603 (10 nM) caused depolarization in both the inspiratory-activated and inspiratory-inhibited airway vagal preganglionic neurons that were retrogradely labeled, and a significant increase in the spontaneous firing rate. Under voltage clamp, A61603 significantly enhanced the spontaneous excitatory inputs to both types of neurons and caused a tonic inward current in the inspiratory-activated neurons along with significantly increased peak amplitude of the inspiratory inward currents. The responses in vitro were prevented by \u03b1<jats:sub>1A<\/jats:sub>-adrenoceptor antagonist RS100329 (1 \u03bcM), which alone significantly inhibited the spontaneous excitatory inputs to both types of the neurons. After pretreatment with tetrodotoxin (1 \u03bcM), A61603 (10 or 100 nM) had no effect on either type of neuron. We conclude that in rats, activation of \u03b1<jats:sub>1<\/jats:sub>-adrenoceptors in the medullary region containing airway vagal preganglionic neurons increases airway vagal tone, and that this effect is primarily mediated by facilitation of the excitatory inputs to the preganglionic neurons.<\/jats:p>","DOI":"10.1152\/japplphysiol.00045.2015","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T02:40:38Z","timestamp":1437705638000},"page":"686-695","source":"Crossref","is-referenced-by-count":10,"title":["Activation of \u03b1<sub>1<\/sub>-adrenoceptors facilitates excitatory inputs to medullary airway vagal preganglionic neurons"],"prefix":"10.1152","volume":"119","author":[{"given":"Dengyun","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, 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