{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:13:57Z","timestamp":1792638837075,"version":"4.5.0"},"reference-count":89,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-19-1-0075"],"award-info":[{"award-number":["W81XWH-19-1-0075"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:p> This work advances our understanding of the pathophysiologic complexity of volumetric muscle loss injury. Specifically, we identified secondary denervation in the muscle remaining after volumetric muscle loss injuries as a novel aspect of the injury sequela. Denervation increased chronically, in parallel with the appearance of irregular morphological characteristics and destabilization of the neuromuscular junction, which is expected to further confound chronic functional impairments. <\/jats:p>","DOI":"10.1152\/japplphysiol.00049.2021","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T17:50:27Z","timestamp":1617904227000},"page":"1614-1625","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Secondary denervation is a chronic pathophysiologic sequela of volumetric muscle loss"],"prefix":"10.1152","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5945-542X","authenticated-orcid":false,"given":"Jacob R.","family":"Sorensen","sequence":"first","affiliation":[{"name":"School of Kinesiology, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"School of Kinesiology, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T.","family":"Corona","sequence":"additional","affiliation":[{"name":"School of Medicine, Wake Forest University, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9285-4908","authenticated-orcid":false,"given":"Sarah M.","family":"Greising","sequence":"additional","affiliation":[{"name":"School of Kinesiology, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201102001-00007"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2014.07.0165"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.10.012"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22730"},{"key":"B5","first-page":"18","volume":"19","author":"Armed Forces Health Surveillance Center","year":"2012","journal-title":"MSMR"},{"key":"B6","first-page":"2","volume":"20","author":"Armed Forces Health Surveillance Center","year":"2013","journal-title":"MSMR"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-018-0053-4"},{"key":"B8","first-page":"30","author":"Rivera JC","year":"2016","journal-title":"US Army Med Dep J"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2019.0207"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1159\/000444673"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000443925"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.07.020"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2019.01.025"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2020.1789608"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.6.1715"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/00003677-200104000-00008"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20150133"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEC.2018.0324"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26016"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3810-0_2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-018-0027-8"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.01.061"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00189.2013"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13306-2"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2015.10.013"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01386.2013"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.01.048"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20173"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.10.015"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1139\/h97-014"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7374-3_5"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3791\/52220"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2018.05.007"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26654"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.08.030"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13249"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2015.0009"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40606-6"},{"key":"B40","first-page":"100","volume":"13","author":"Sulaiman W","year":"2013","journal-title":"Ochsner J"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.9.919"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028090"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.6.2235"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45923-4"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00207"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3171\/2020.8.JNS201461"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-016-9937-7"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2003.10.004"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.08.029"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2015.0506"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.7.1.015003"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(86)90023-7"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10032-1"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-09-05672.1994"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4569"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.4.789"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.156944"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1768-z"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225013806"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.03.007"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1080\/00207450590882172"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt659"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00252"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1663-7"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00099"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002220107"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(90)90076-Y"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.09.012"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120154"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239152"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-018-2095-6"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1186\/2052-1847-6-41"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2013.07.037"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000000673"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00689.2014"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2019.0272"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.143424"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-020-0096-1"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2020.1776707"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01036-12"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx023"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-016-0105-7"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00026.2019"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1736-20.2020"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.021"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56935"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034640"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09221"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2021.1886285"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00049.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T09:02:11Z","timestamp":1624438931000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00049.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":89,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,1]]}},"alternative-id":["10.1152\/japplphysiol.00049.2021"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00049.2021","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]},"assertion":[{"value":"2021-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}