{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:39:47Z","timestamp":1790206787632,"version":"4.1.0"},"reference-count":76,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>\n                    Breathing patterns in preterm infants consist of highly variable interbreath intervals (IBIs) that might originate from nonlinear properties of the respiratory oscillator and its input-output responses to peripheral and central signals. Here, we explore a property of nonlinear control, the potential for large improvement in the stability of breathing using low-level exogenous stochastic stimulation. Stimulation was administered to 10 preterm infants (postconceptional age: mean 33.3 wk, SD 1.7) using a mattress with embedded actuators that delivered small stochastic displacements (0.021 mm root mean square, 0.090 mm maximum, 30\u201360 Hz); this stimulus was subthreshold for causing arousal from sleep to wakefulness or other detectable changes in the behavioral state evaluated with polysomnography. We used a test-retest protocol with multiple 10-min intervals of stimulation, each paired with 10-min intervals of no stimulation. Stimulation induced an \u223c50% reduction ( P = 0.003) in the variance of IBIs and an \u223c50% reduction ( P = 0.002) in the incidence of IBIs &gt; 5 s. The improved stability of eupneic breathing was associated with an \u223c65% reduction ( P = 0.04) in the duration of O\n                    <jats:sub>2<\/jats:sub>\n                    desaturation. Our findings suggest that nonlinear properties of the immature respiratory control system can be harnessed using afferent stimuli to stabilize eupneic breathing, thereby potentially reducing the incidence of apnea and hypoxia.\n                  <\/jats:p>","DOI":"10.1152\/japplphysiol.00058.2009","type":"journal-article","created":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T21:45:16Z","timestamp":1247780716000},"page":"1017-1027","source":"Crossref","is-referenced-by-count":93,"title":["Stabilizing immature breathing patterns of preterm infants using stochastic mechanosensory stimulation"],"prefix":"10.1152","volume":"107","author":[{"given":"Elisabeth","family":"Bloch-Salisbury","sequence":"first","affiliation":[{"name":"Department of 1Neurology, University of Massachusetts Medical School, Worcester, Massachusetts"},{"name":"Department of 2Pediatrics (Neonatology), University of Massachusetts Medical School, Worcester, Massachusetts 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