{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:19:58Z","timestamp":1787617198499,"version":"build-2736575974"},"reference-count":39,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","award":["Trustee grant"],"award-info":[{"award-number":["Trustee grant"]}],"id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>This study introduces an in vivo swine model to simultaneously assess how albuterol alters tracheal and lung compliance. Albuterol increased compliance in both regions, potentially exacerbating airway collapse in tracheomalacia. These findings clarify the paradoxical effects of bronchodilators and emphasize the importance of individualized respiratory management for pediatric patients with airway abnormalities often mistaken for asthma.<\/jats:p>","DOI":"10.1152\/japplphysiol.00064.2026","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T14:52:37Z","timestamp":1785595957000},"page":"795-801","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of albuterol on compliance and distensibility of the trachea and lungs"],"prefix":"10.1152","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-6533","authenticated-orcid":false,"given":"Chamindu C.","family":"Gunatilaka","sequence":"first","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]},{"name":"University of Cincinnati","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"McConnell","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Sketch","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-7524","authenticated-orcid":false,"given":"Carolyn","family":"Doerning","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Hales","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie","family":"Cummins","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Schierling","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kaul","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8080-7511","authenticated-orcid":false,"given":"Jason C.","family":"Woods","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]},{"name":"University of Cincinnati","place":["United States"]},{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-3448","authenticated-orcid":false,"given":"Alister J.","family":"Bates","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]},{"name":"University of Cincinnati","place":["United States"]},{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]},{"name":"University of Cincinnati","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-898X","authenticated-orcid":false,"given":"Erik B.","family":"Hysinger","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center","place":["United States"]},{"name":"University of Cincinnati","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3391"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1046\/J.1460-9592.2003.01207.X"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1148\/88.4.653"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/PPUL.1950090309"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198612000-00002"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00382-2019"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202002-162OC"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2017.00080"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/LARY.28656"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1513\/ANNALSATS.202009-1142RL"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2283"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/PPUL.20549"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.02.035"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1165\/RCMB.2013-0453TR"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1964.19.2.207"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2006.01.015"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2015.11.033"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2009.2021652"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.104099"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199806000-00018"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/S41372-023-01799-X"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1136\/ADC.88.3.246"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/S001340050937"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201702-178OC"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/PPUL.27383"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-3350"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/S12931-017-0646-2"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-6"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S220164"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132009000400006"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1159\/000194470"},{"key":"B32","doi-asserted-by":"publisher","unstructured":"Hughes DM, Lesou\u00ebf PN, Landau LI. Effect of salbutamol on respiratory mechanics in bronchiolitis. Pediatr Res 22: 83\u201386, 1987. doi:10.1203\/00006450-198707000-00019. 3627878","DOI":"10.1203\/00006450-198707000-00019"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199903)27:3"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00753-2019"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000448"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1089\/PED.2018.0880"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1177\/1089253214548804"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.11.034"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26296"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00064.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:29:47Z","timestamp":1787614187000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00064.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1152\/japplphysiol.00064.2026"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00064.2026","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}