{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:25:47Z","timestamp":1769412347074,"version":"3.49.0"},"reference-count":29,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p> Recent studies have demonstrated that oxygen-sensitive type I cells in the carotid body express the gap junction-forming protein connexin43 (Cx43). In the present study, we examined the hypothesis that chronic exposure to hypoxia increases Cx43 expression in type I cells as well as in chemoafferent neurons in the petrosal ganglion. Immunocytochemical studies in tissues from normal rats revealed diffuse and granular Cx43-like immunoreactivity in the cytoplasm of type I cells and dense punctate spots of immunoreactive product at the margins of type I cells and near the borders of chemosensory cell lobules. Cx43-like immunoreactivity was not detectable in petrosal ganglion neurons from normal animals. After a 2-wk exposure to hypobaric (380 Torr) hypoxia, Cx43 immunostaining was substantially enhanced in and around type I cells. Moreover, chronic hypoxia elicited the expression of Cx43-like immunoreactivity in the cytoplasm of afferent neurons throughout the petrosal ganglion. Quantitative RT-PCR studies indicate that chronic hypoxia evokes a substantial increase in Cx43 mRNA levels in the carotid body, along with a marked elevation of Cx43 expression in the petrosal ganglion. Increased Cx43 expression and gap junction formation in type I cells and sensory neurons may contribute to carotid body adaptation during sustained stimulation in extreme physiological conditions. <\/jats:p>","DOI":"10.1152\/japplphysiol.00077.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:40:08Z","timestamp":1425397208000},"page":"1480-1486","source":"Crossref","is-referenced-by-count":33,"title":["Chronic hypoxia upregulates connexin43 expression  in rat carotid body and petrosal ganglion"],"prefix":"10.1152","volume":"92","author":[{"given":"J.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Utah, Salt Lake City, Utah 84108"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Utah, Salt Lake City, Utah 84108"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Dinger","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Utah, Salt Lake City, Utah 84108"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Stensaas","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Utah, Salt Lake City, Utah 84108"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fidone","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Utah, Salt Lake City, Utah 84108"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.4.1635"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91982-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00344-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00127-9"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01946-0"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.2.685"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018560803261"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90241-Q"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2572-1_10"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1159\/000109455"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00131-6"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0001q.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00272-8"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb11376.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2966-8_55"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-46825-5_32"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00020-1"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00545-G"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb13402.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.4.829"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1979.tb05216.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.2000.0288"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/BF01098781"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.5.8404689"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90810-A"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.44.5.763"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1159\/000024053"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.6.2403"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/BF00268878"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00077.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:28:59Z","timestamp":1567956539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00077.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4,1]]}},"alternative-id":["10.1152\/japplphysiol.00077.2001"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00077.2001","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,1]]}}}