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Posterior ocular globe flattening has been identified in astronauts with SANS but until now has not been investigated during HDT bed rest. In this study, posterior ocular globe volume displacement was quantified before, during, and after HDT bed rest and countermeasures were tested for their potential to reduce the degree of globe flattening.<\/jats:p>","DOI":"10.1152\/japplphysiol.00082.2022","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T09:37:12Z","timestamp":1667468232000},"page":"1349-1355","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6\u00b0 head-down tilt bed rest with and without daily centrifugation"],"prefix":"10.1152","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-0900","authenticated-orcid":false,"given":"Stuart H.","family":"Sater","sequence":"first","affiliation":[{"name":"Alcyone Therapeutics Inc., Lowell, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabryel","family":"Conley Natividad","sequence":"additional","affiliation":[{"name":"Alcyone Therapeutics Inc., Lowell, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari J.","family":"Seiner","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, University of Idaho, Moscow, Idaho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey Q.","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistical Science, Institute of Bioinformatics and Evolutionary Studies, Institute for Modeling Collaboration & Innovation, University of Idaho, Moscow, Idaho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dev","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, University of Idaho, Moscow, Idaho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Bershad","sequence":"additional","affiliation":[{"name":"Department of Neurology, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5240-7625","authenticated-orcid":false,"given":"Karina","family":"Marshall-Goebel","sequence":"additional","affiliation":[{"name":"KBR, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-3583","authenticated-orcid":false,"given":"Steven S.","family":"Laurie","sequence":"additional","affiliation":[{"name":"KBR, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2527-5089","authenticated-orcid":false,"given":"Brandon R.","family":"Macias","sequence":"additional","affiliation":[{"name":"Cardiovascular and Vision Laboratory, Johnson Space Center, National Aeronautics and Space Administration, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-7880","authenticated-orcid":false,"given":"Bryn A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Alcyone Therapeutics Inc., Lowell, Massachusetts"},{"name":"Department of Chemical and Biological Engineering, University of Idaho, Moscow, Idaho"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31829b41a6"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0070-y"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.06.021"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.actaastro.2013.01.014"},{"key":"B5","unstructured":"Stenger MB, Tarver WJ, Brunstetter T, Gibson CR, Laurie SS, Lee SMC, Macias BR, Mader TH, Otto C, Smith SM, Zwart SR. 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